Abstract
Platinum was determined by the inductively coupled plasma mass spectrometry (ICP-MS) in the intervertebral discs and vertebrae of ovarian tumor bearing patients treated withcis-diamminedichloro-platinum (II) (cisplatin). Platinum was 0.05 ng/mL at the absolute detection limit, and platinum was undetectable in the intervertebral discs and vertebrae of human specimens without cisplatin treatments. On the other hand, platinum was detected in the intervertebral discs and vertebrae of patients administered cisplatin, and platinum concentration was at levels of 1.06–10.31 μg/g dry tissue in the intervertebral discs and 0.60–1.28 μg/g dry tissue in the vertebrae, respectively. The platinum level of intervertebral discs was 4.3-fold higher than that of the vertebrae.
Thus, platinum accumulates greatly in the intervertebral discs and somewhat in the vertebrae after administering cisplatin to patients for therapy.
Similar content being viewed by others
References
J. W. Yarbro, R. S. Bornsteen, and M. J. Mastrangelo (eds),Semin. Oncol. 16 (Supple. 6), 1 (18).
J. M. Hill, E. Loeb, A. MacLellan, N. O. Hill, A. Khan, and J. J. King,Cancer Chemother. Rep. 59, 647 (1975).
R. B. Vance and J. P. Kapp,J. Neuro-Oncol. 3, 287 (1986).
L. G. Feun, S. Wallace, D. J. Stewart, V. P. Chuang, W. A. Yung, M. E. Leavens, M. A. Burgess, N. Savaraj, R. S. Benjamin, S. E. Young, R. A. Tang, S. Handel, G. Mavligit, and W. S. Fields,Cancer 54, 794 (1984).
J. Z. Ginos, A. J. L. Cooper, V. Dhawan, J. C. K. Lai, S. C. Strother, N. Alcock, and D. A. Rottenberg,J. Nucl. Med. 28, 1844 (1987).
B. Lippert,BioMetals 5, 195 (1992).
D. E. Szymkowski, K. Yarema, J. M. Essigmann, S. J. Lippard, and R. D. Wood,Proc. Natl. Acad. Sci. USA 89, 10772 (1992).
T. Yasumasu, T. Ueda, J. Uozumi, Y. Mihara, Y. Koikawa, and J. Kumazawa,J. Pharm. Pharmacol. 44, 885 (1992).
T. W. Jones, S. Chopra, J. S. Kaufman, W. Flamenbaum, and B. F. Trump,Lab. Invest. 52, 363 (1985).
R. W. Gregg, J. M. Molepo, V. J. A. Monpetit, N. Z. Mikael, D. Redmond, M. Gadia, and D. J. Stewart,J. Clin. Oncol. 10, 795 (1992).
R. I. Roelofs, W. Hrushesky, J. Rogin, and L. Rosenberg,Neurology 34, 934 (1984).
J. E. Molleman, W. M. Hogan, D. J. Glover, and L. F. McCluskey,Neurology 38, 488 (1988).
F. P. T. Hamers, J. H. Brakkee, E. Cavalletti, M. Tedeschi, L. Marmonti, G. Pezzoni, J. P. Neijt, and W. H. Gispen,Cancer Res. 53, 544 (1993).
S. K. Aggarwal, N. W. Gemma, M. Kinter, J. Nicholson, J. R. Shipe, Jr., and D. A. Herold,Anal. Biochem. 210, 113 (1993).
T. Irie, Y. Hashimoto, A. Irie, M. Ishibashi, H. Miyazaki, H. Machida, Y. Karasawa, and K. Nakamori,Iyakuhin Kenkyu 14, 384 (1983) (in Japanese).
F. V. P. Duffield, A. Yoakum, J. Bumgarner, and J. Moran,Environ. Health Perspect.15, 131 (1976).
A. M. Yoakum, P. L. Stewart, and J. E. Sterrett,Environ. Health Perspect. 10, 85 (1975).
R. F. Ozols, and R. C. Young,Semin. Oncol. 12 (Supple. 6), 21 (1985).
S. W. Thompson, L. E. Davis, M. Kornfeld, R. D. Hilgers, and J. C. Standefer,Cancer 54, 1269 (1984).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Minami, T., Hashii, K., Tateyama, I. et al. Accumulation of platinum in the intervertebral discs and vertebrae of ovarian tumor-bearing patients treated with cisplatin. Biol Trace Elem Res 42, 253–257 (1994). https://doi.org/10.1007/BF02911522
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02911522