Summary
To study the expression of hypoxia inducible factor-1α (HIF-1α) protein in prostate cancer (Pca) and its biological significance, the expression of HIF-1α was assayed by means of immunohistochemical technique in 12 prostate cancer. 12 prostatic intraepithelial neoplasm (PIN) and 9 normal prostate tissue (NP) specimens. Western blot was used to examine the expression of HIF-1α in prostate cancer cell line (PC-3M) induced by different oxygen tension. HIF-1α expression was positive in 33 Pca and 9 PIN specimens, and the positive rate of HIF-1α was higher in distant metastasis patients than in patients without metastasis of prostate cancer (P<0.05), while there was no expression of HIF-1α in NP. The level of HIF-1α in PC-3M significantly increased with the decrease of oxygen tension (P<0.01). Overexpression of HIF-1α is the preliminary event of the formation of Pca, which may induce carcinoma into malignant phenotype. Thus it may serve as an early diagnosis marker and the novel target for Pca treatment.
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PING Hao, male, born in 1977. M.D., Ph.D.
This project was supported by a grant from the National Natural Science Foundation of China (No. 30070756).
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Hao, P., Xiaochun, C., Huaizhen, G. et al. Expression and implication of hypoxia inducible factor-1α in prostate neoplasm. Current Medical Science 24, 593–595 (2004). https://doi.org/10.1007/BF02911365
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DOI: https://doi.org/10.1007/BF02911365