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Mosquito repelling activity of compounds occurring inAchillea millefolium L. (asteraceae)

Mückenabschreckende aktivität von substanzen ausachillea millefolium L.

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Abstract

An ethanol extract ofAchillea millefolium L. showed repelling properties against the mosquito,Aedes aegypti L. Prepared fractions from the extract contained several active compounds which were characterized by thin layer chromatography, high performance liquid chromatography, gas chromatography and mass spectroscopy. Of 35 compounds tested, the most active were the nitrogen containing compound stachydrine, the carboxylic acids, caffeic, chlorogenic, and salicylic acids, and the phenolic compound pyrocatechol. These substances are earlier reported to occur inA. millefolium with the exception of pyrocatechol. Some further substances with lower activity were characterized for the first time inA. millefolium, i.e., adenine, ferulic and mandelic acid, and the methyl esters of capryliclinolenic- and undecylenic acid.

Zusammenfassung

Der Ethanolextrakt vonA. millefolium zeigte abwehrende Eigenschaften gegen die MückeAedes aegypti L. Die aus diesem Extrakt hergestellten Fraktionen enthielten mehrere aktive Verbindungen, die mittels Ditnnschichtchromatographie, Gaschromatographie und Massenspektrometrie charakterisiert wurden. Von den 35 untersuchten Substanzen waren die stickstoffhaltige Verbindung Stachydrin, die sauren Verbindungen Kaffee-, Chlorogen- und Salicylsäure sowie das Brenzcatechin die aktivsten. Diese Substanzen sind mit Ausnahme des Brenzcatechins schonfrüher aus A. millefolium beschrieben worden. Weiterhin wurden Adenin, Ferula- und Mandelsäure sowie die Methylestern der Capryl-, Linolen- und Undecylensäure als schwächer aktive Substanzen zum ersten Mal ausA. millefolium charakterisiert.

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  1. Department of Pharmacy, Division of Pharmacognosy, Biomedical Centre, Uppsala University, Box 579, S-751 23, Uppsala, Sweden

    H. Tunón, W. Thorsell & L. Bohlin

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Tunón, H., Thorsell, W. & Bohlin, L. Mosquito repelling activity of compounds occurring inAchillea millefolium L. (asteraceae). Econ Bot 48, 111–120 (1994). https://doi.org/10.1007/BF02908196

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