Skip to main content

Advertisement

SpringerLink
Log in

Polychondritis terminating in Eosinophilic Leukemia

  • Case Report
  • Published:
Pathology & Oncology Research

Abstract

We report here on a patient presenting with Relapsing Polychondritis (RP) two years before the diagnosis of Myelodysplasia (MDS) terminating in Eosinophilic Leukemia (EoL). The evolution of RP several years prior to the presentation of MDS does not support a paraneoplastic etiology of RP in this patient. The terminal development of EoL in our case is assumed to represent clonal evolution caused by a second mutagenic event. The existence of autoimmune skin disorders in both the patient and his offspring (vitiligo and subacute cutaneous lupus erythematosus, respectively) implies that the coexistence of MDS and RP may have been caused by a functional disturbance of the immune system.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Castro M,Conn DL, Su WP, Garton JP: Rheumatic manifestations in myelodysplatic syndromes. J Rheumatology 18:721–727, 1991.

    CAS  Google Scholar 

  2. Diebold J, Rauh G, Jager K, Löhrs U: Bone marrow pathology in relapsing polychondritis: high frequency of myelodysplastic syndromes. Brit J Haemat 9:820–830, 1995.

    Google Scholar 

  3. Bynoe AG, Scott CS, Ford P, Roberts BE: Decreased T helper cells in the myelodysplastic syndromes. Brit J Haemat 54:97–102, 1983

    Article  PubMed  CAS  Google Scholar 

  4. Economopoulos T, Economidous J, Giannapoulos G, et al: Immune abnormalities in myelodysplastic syndromes. J Clin Path 38:908–911, 1985

    Article  PubMed  CAS  Google Scholar 

  5. Ebringer R, Rook G, Swana GT, et al: Autoantibodies to cartilage and type II collagen in relapsing polychondritis and other rheumatic diseases. Ann Rheum Dis 40:473–479, 1985

    Google Scholar 

  6. Anstey A, Mayou S, Morgan K, et al: Relapsing polychondritis: autoimmunitiy to type II collagen and treatment with cyclosporin A. Brit J Dermatology 125:588–591, 1991.

    Article  CAS  Google Scholar 

  7. Michet CJ, McKenna CH, Luthra HS, O. Fallon WM: Relapsing Polychondritis. Survival and predictive role of early disease manifestations. Clinical review. Ann Intern Med 104:74–78, 1986.

    PubMed  Google Scholar 

  8. Me Adam LP, O'Hanlan MA, Bluestone R, Pearson CM: Relapsing Polychondritis: Prospective study of 23 patients and a review of the literature. Medicine 553:193–215, 1976

    Google Scholar 

  9. Besten KV, Tricot G, Hoffman R: Relapsing polychondritis: A paraneoplastic syndrome associated with myelodysplastic syndromes. Am J Hematology 40:47–50, 1992.

    Article  Google Scholar 

  10. Shirota T, .Hayashi H, Uchida M, et al: Myelodysplastic syndrome associated with relapsing polychondritis: unusual transformation from refractory anemia to chronic myelomonocytic leukemia. Ann Hemat 67:45–47, 1993.

    Article  CAS  Google Scholar 

  11. Arlet Ph, Pris J, Sallerin F, et al: Polychondrite chronique atrophiante. Particularités cliniques. Press Med. 18:157–160, 1989.

    CAS  Google Scholar 

  12. Matsushima T, Murakami H, Sawamura M, et al: Myelodysplastic syndrome with eosinophilia in bone marrow. Brit J Haemat 84:636–638, 1993.

    Article  PubMed  CAS  Google Scholar 

  13. Murakawa M., Shibuya T, Taniguchi S, et al: Acute eosinophilic leukemia in a patient with preexistent myelodysplastic syndrome. Acta Haemat 86:42–45, 1991.

    PubMed  CAS  Google Scholar 

  14. Pérez-Losada A,Woessner S, Solé F, et al: Refractory anaemia with hypereosinophilia and clonal abnormal metaphases detected only in the neutrophilic granulopoietic series. Acta Haemat 91:80–83, 1994.

    PubMed  Google Scholar 

  15. Yano A, Yasukawa M, Yanagisawa K, et al: Adult T cell leukemia associated with eosinophilia: analysis of eosinophil- stimulating factors produced by leukemic cells. Acta Haematol 88:207–212, 1992.

    Article  PubMed  CAS  Google Scholar 

  16. Iscove NN, Sieber F: Erythroid progenitors in mouse bone marrow detected by macroscopic colony formation in culture. Exp Haemat 3:32, 1975.

    CAS  Google Scholar 

  17. Coutinho LH, Gilleece MH, DeWynter EA et al: Clonal and long -term cultures using human bone marrow; in Testa NG, Molineux GH (ed): Haemopoiesis. A practical approach. Oxford, New York, Tokyo, Oxford University Press, p 75, 1993.

    Google Scholar 

  18. Malbrain M LNG, Van den Bergh H, Zachee P: Further evidence for the clonal nature of the idiopathic hypereosinophilic syndrome: complete haematological and cytogenetic remission induced by interferon-alpha in a case with a unique chromosomal abnormality. Brit J Haemat 92:176–183, 1996.

    Article  PubMed  CAS  Google Scholar 

  19. Benvenisti DS, Ultman JE: Eosinophilic leukemia. Report of five cases and review of literature. Ann Intern Med 71:731–745, 1969.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine, Semmelweis University, 12 Eötvös út, H-l 121, Budapest, Hungary

    Judit VÁrkonyi, Lajos Jakab & Tamás Szombathy

  2. Institute of Pathology and Experimental Cancer Research, Semmelweis University, Budapest

    Attila Zalatnay & Péter Nagy

  3. Department of Ophthalmology, Semmelweis University, Budapest

    Rita VÁmos

Authors
  1. Judit VÁrkonyi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lajos Jakab
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Attila Zalatnay
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Péter Nagy
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Rita VÁmos
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Tamás Szombathy
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

VÁrkonyi, J., Jakab, L., Zalatnay, A. et al. Polychondritis terminating in Eosinophilic Leukemia. Pathol. Oncol. Res. 3, 135–138 (1997). https://doi.org/10.1007/BF02907809

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02907809

Keywords

Search

Navigation