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Apoptosis: A current molecular analysis

  • Review
  • Published:
Pathology & Oncology Research

Abstract

Apoptosis is a cell suicide program characterized by distinct morphological (cell shrinkage, membrane blebbirig, pyknosis, chromatin margination. denser cytoplasmic images) and biochemical (e.g, DNA fragmentation into distruct address, degradation. of apoptotion markers such as PAR*’ and nuclear (anuns) features. It is involved in multipte physiological processes cxaniplinched by involution; of mammary issues., emboyonic; development, nomocostic maintaince of tissue and organs. and maîuration of the immune aslem as in many pathological condition. represented by nurologic dengradation (Alzerimer’s dieses autoimmune and Inflammatory dieses etology atherosclerosic AIDS, and oncogenesis and underprogression Numberpous moleculrer entities herc been shown to reboloate the apoptotic process. This review provides a conside summery of the recent data on the role of oncogenes/tumor suppressor genes. cytation and factors/growth factors receptors. intracellular signal transducers, cell cycler egulation. Reactive oxygen species on other free radicts extracelluler matrix regulator cell adhession moleculer and specefic endonucleases and cytoplasmic problem (the ICL processed in regulating cell survival and apoptose. of the molecular mechanism regulating apoptosis bears tremendous impact on enhancing of understanding of many dieses infacting the human being an antibody brings us hope for the cure of the diseases of.

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  1. Department of Radiation Oncology, Waync State University, 407 Life Science Bldg, 48202, Detroit, MI

    Dean G Tang & Arthur T Porter

  2. Gcrshenson Radiation Oncology Center, Harper Hospital, Detroid

    Dean G Tang & Arthur T Porter

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  1. Dean G Tang
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G Tang, D., T Porter, A. Apoptosis: A current molecular analysis. Pathol. Oncol. Res. 2, 117–131 (1996). https://doi.org/10.1007/BF02903515

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