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Multi-scaling hierarchical structure analysis on the sequence ofE. coli complete genome

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Chinese Science Bulletin

Abstract

We have applied the newly developed hierarchical structure theory for complex systems to analyze the multi-scaling structures of the nucleotide density distribution along a linear DNA sequence from the completeEscherichia coli genome. The hierarchical symmetry in the nucleotide density distribution was demonstrated. In particular, we have shown that the G, C density distribution that represents a strong H-bonding between the two DNA chains is more coherent with smaller similarity parameter compared to that of A, T density distribution, indicating a better organized multi-scaling fluctuation field for G, C density distribution along the genome sequence. The biological significance of these findings is under investigation.

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Authors and Affiliations

  1. State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, 210093, Nanjing, China

    Jin Wang & Qidong Zhang

  2. State Key Laboratory for Studies of Turbulence and Complex Systems, Department of Mechanics and Engineering Science, Peking University, 100871, Beijing, China

    Kui Ren & Zhensu She

  3. Department of Geophysics, Peking University, 100871, Beijing, China

    Kui Ren

Authors
  1. Jin Wang
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  2. Qidong Zhang
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  3. Kui Ren
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  4. Zhensu She
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Correspondence to Jin Wang.

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Wang, J., Zhang, Q., Ren, K. et al. Multi-scaling hierarchical structure analysis on the sequence ofE. coli complete genome. Chin.Sci.Bull. 46, 1988–1991 (2001). https://doi.org/10.1007/BF02901913

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  • DOI: https://doi.org/10.1007/BF02901913

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