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Induction of multi-epitopespecific antibodies against HIV-1 by multi-epitopevaccines

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Chinese Science Bulletin

Abstract

Some neutralizing antibodies against HIV-1 envelope proteins were highly effective to inhibit the infection of different strainsin vitro, and existed in the infected individuals with very low levels. We suggested multi-epitope-vaccine as a new strategy to increase levels of neutralizing antibodies and the abilities against HIV mutationin vivo. Two candidate multi-epitope-vaccines induced antibodies with predefined multi-epitope-specificity in rhesus macaque. These antibodies recognized corresponding neutralizing epitopes on epitope-peptides, gp41 peptides, V3 loop peptide, rsgp41 and rgp120. Besides, three candidate epitope-vaccines in combination (another kind of multi-epitopevaccines) showed similar potency to induce predefined multiple immune responses in rabbits. These results suggest that multi-epitope-vaccines may be a new strategy to induce multi-antiviral activities against HIV-1 infection and mutations.

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Authors and Affiliations

  1. Laboratory of Immunology, Research Center for Medical Science and Department of Biology, Tsinghua University Protein Science Laboratory of Ministry of Education of China, 100084, Beijing, China

    Jian Ding, Fei He, Yun Lu, Yi Xiao & Yinghua Chen

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  1. Jian Ding
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  2. Fei He
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  3. Yun Lu
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  4. Yi Xiao
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  5. Yinghua Chen
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Correspondence to Yinghua Chen.

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Ding, J., He, F., Lu, Y. et al. Induction of multi-epitopespecific antibodies against HIV-1 by multi-epitopevaccines. Chin.Sci.Bull. 46, 1859–1864 (2001). https://doi.org/10.1007/BF02901157

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  • DOI: https://doi.org/10.1007/BF02901157

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