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The role of insulin-like growth factors and IGF-binding proteins in the physiological and pathological processes of the kidney

  • Review
  • Published:
Virchows Archiv B

Summary

Insulin-like growth factors (IGFs) and their binding proteins are implicated in the growth regulation of the kidney during embryogenesis and differentiation. Recent evidence also suggests that IGFs play a role in kidney physiology (glomerular filtration rate, renal plasma flow) and pathology (diabetic renal hypertrophy, nephritis, glomerulosclerosis, kidney tumours, chronic renal failure).

This review focuses on the biology of IGFs at the molecular, protein and receptor levels and considers their importance in renal physiology and pathology. The current data demonstrate a central role for the IGFs in the mediation of a wide variety of effects on renal growth, function and malignancy.

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  1. Institute of Child Health, University of London, London, UK

    Walter Zumkeller

  2. Department of Anatomy, University of Cambridge, Cambridge, UK

    Walter Zumkeller & Paul N. Schofield

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Zumkeller, W., Schofield, P.N. The role of insulin-like growth factors and IGF-binding proteins in the physiological and pathological processes of the kidney. Virchows Archiv B Cell Pathol 62, 207–220 (1992). https://doi.org/10.1007/BF02899684

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