Summary
Tracheal papillomas in the Syrian golden hamster were induced with diethylnitrosamine (DEN). Intracytoplasmic lumina filled with mucus were studied by light and electron microscopy. The sequence of lumen genesis is described ultrastructurally. Mucus substances in the center of intracytoplasmic lumen are presumed to be condensations of cell coat macromolecules. The intracytoplasmic lumen is discussed as a common feature of the adenoid component in epithelial neoplasms.
Similar content being viewed by others
References
Althoff J, Wilson R, Mohr U (1971) Diethylnitrosamine-induced alterations in the tracheobronchial system of Syrian golden hamster. J Natl Cancer Inst 46:1067–1071
Becci P, McDowell E, Trump B (1978) The respiratory epithelium. VI. Histogenesis of lung tumors in Benzo(a)-pyreneferric oxide in the hamster. J Natl Cancer Inst 61:607–618
Chejfec, G., Capella, C., Solcia, E., Jao, W, Gould, V (1985) Amphicrine cells, dysplasias, and neoplasias. Cancer 56:2683–2690
Chomette, G., Auriol, M., Delcourt, A, Terean, Y (1980) Contribution to the histogenesis of lobular carcinoma of the breast. Annales d’anatomie pathol 25:85–94
Del Cerro, M., Cogen, J, Del Cerro, C (1980) Stevenel’s blue, an excellent stain for optical microscopical study of plastic embedded tissues. Microsc Acta 83:117–121
Klein-Szanto, A., Topping, D., Heckman, C, Nettesheim, P (1980) Ultrastructural characteristics of carcinogen-induced dysplastic changes in tracheal epithelium. Am J Pathol 98:83–100
Luft JH (1976) The structure and properties of the cell surface coat. Int Rev Cytol 45:291–382
McDowell E, Trump B (1983) Histogenesis of preneoplastic and neoplastic lesions in trancheobronchial epithelium. Surv Synth Pathol Res 2:235–279
McDowell E, McLaughlin J, Merenyl D, Kleffer R, Harris C, Trump B (1978) The respiratory epithelium. V. Histogenesis of lung carcinomas in the human. J Natl Cancer Inst 61:587–606
McDowell E, Harris C, Trump B (1982) Histogenesis and morphogenesis of bronchial neoplasms. In: Shimosato Y (ed) Morphogenesis of lung cancer vol 1. CRC Press, Boca Raton, pp 1–36
Mohr U (1982) Tumors of the respiratory tract. In: Turusov V. (ed) Pathology of tumors in laboratory animals. IARC Scientific Publications No 34, Lyon pp 115–146
Rainio P (1983) Ultrastructure of neoplastic cells in different histologie subtypes of pulmonary adenocarcinoma. Pathol Res Pract 1976:216–235
Reznik-Schüller, H (1980) Pathogenesis of Diethylnitrosamineinduced tumors in the trachea of the Syrian golden hamster. Pathol Res Path 168:185–192
Reznik-Schüller, H, Mohr, U (1974) Morphological changes in the tracheal epithelium in Syrian golden hamster during the first 20 weeks of benzo(a)pyrene instillation: an ultrastructural study. Zb Bakt Hyg [I Abt Orig B] 159:503–525
Roseman, S (1975) Sugars of the cell membrane. In: Weissmann G, Claiborne R (eds) Cell membranes: biochemistry, cell biology and pathology. Hospital Practice, New York, pp 55–64
Steinbrecher JS, Silverberg SG (1976) Signet-ring cell carcinoma of the breast. Cancer 37:828–840
Wahnschaffe U (1985) A method for reembedding semithin sections for ultrathin sectioning. Mikroskopie 42:108–110
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wahnschaffe, U., Emura, M. & Mohr, U. Development of intracytoplasmic lumina in diethylnitrosamine-induced tracheal papillomas of Syrian golden hamster. Virchows Archiv B Cell Pathol 54, 59–66 (1987). https://doi.org/10.1007/BF02899197
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02899197