Abstract
The facultative intracellular Gram-positive bacteriumListeria monocytogenes is a food-borne pathogen of frequently underestimated importance. Pregnant women represent the high-risk group forL. monocytogenes infection. Abortion, stillbirth or neonatal infection can be the serious outcome of such an infection. Recovery from listeriosis, resistance mechanisms of the host and the effect ofL. monocytogenes on fetal development still remain to be fully understood. The results of our experiments showed an increased susceptibility of gestating BALB/c mice to primaryL. monocytogenes infection. The duration of listeriosis in gestating animals was almost twice longer than in the control group. Furthermore, it was clearly shown that the detrimental effect ofL. monocytogenes on fetal development was more pronounced if the infection was acquired earlier during gestation.
Similar content being viewed by others
References
Andriole V.T.: Urinary tract infections in pregnancy.Urol.Clin.North Am. 2, 485–497 (1975).
Bobé P., Dorić M., Kinsky R.G., Voisin G.A.: Modulation of mouse anti-SRBC antibody response by placental extracts.Cell. Immunol. 89, 355–364 (1984).
Cobbold S.P., Jayassuriya A., Nash A., Prospero T.D., Waldman H.: Therapy with monoclonal antibodies by elimination of T-cell subsetsin vivo.Nature (London)312, 548–550 (1984).
Dorić M., Kinsky R.G., Voisin G.A.: Allogeneic reactivity of maternal lymphoid cells during the course of gestation. Modification and sex difference in a local GVH assay.J.Reproduct.Imm. 6, 187–195 (1984).
Dorić M., Rukavina D.: Alterations in immunological reactivity during pregnancy in mice determinedin vitro by lymphoproliferation tests.Immunobiology 175, 236–244 (1987).
Fabris N.: Immunologic reactivity during pregnancy in the mouse.Experientia 29, 610–612 (1973).
Fakhoury G.W.: Complications of listeroisis during pregnancy and neonatal period.J.Obst.Gynaecol. 7, 124–125 (1986).
Hahn H., Kaufmann S.H.E.: The role of cell-mediated immunity in bacterial infections.Rev.Infect.Dis. 3, 1221–1250 (1981).
Hedvall E.: Pregnancy and tuberculosis.Acta Med.Scand. 147 (Suppl. 286), 1–101 (1953).
Hume O.S.: MaternalListeria monocytogenes septicemia with sparing of the fetus.Obst.Gynecol. 48 (Suppl.), 33–34 (1976).
Jonjić S., Mutter W., Weiland F., Reddehase M.J., Koszinowski U.H.: Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+T lymphocytes.J.Exp.Med. 169, 1199–1212 (1989).
Klink M., Rudnicka V.:Listeria monocytogenes infection in pregnant mice: Abnormalities in the function of non-adherent accessory light density dendritic cells.FEMS Immunol.Med.Microbiol. 12, 143–152 (1995).
Lammerding A.M., Glass K.A., Genderon-Fitzpatrick A., Doyle M.P.: Determination of virulence of different strains ofListeria monocytogenes andListeria innocua by oral inoculation of pregnant mice.Appl.Env.Microbiol. 58, 3991 (1992).
Lucas A.O.: Pneumococcal meningitis in pregnancy and the puerperium.Brit.Med.J. 1, 92–95 (1964).
Mackaness G.B.: Cellular resistance to infection.J.Exp.Med. 116, 381–406 (1962).
McLauchlin J.: Human listeriosis in Britain, 1967–85, a summary of 722 cases. 1. Listeriosis during pregnancy and the newborn.Epidemiol.Infect. 104, 181–189 (1990).
North R.J.: Cellular mediators of anti-listeria immunity as an enlarged population of short-lived replicating T cells.J.Exp.Med. 138, 342–355 (1973).
Redline R.W., Lu C.Y.: Specific defects in the anti-listerial immune response in discrete regions of the murine uterus and placenta account for susceptibility to infection.J.Immunol. 140, 3947–3955 (1988).
Tallon D.F., Darch Corcoran D.J., O’Dwyer E.M., Greally J.F.: Circulating lymphocyte subpopulations in pregnancy: a longitudinal study.J.Immunol. 132, 1784–1787 (1984).
Weinberg E.D.: Pregnancy-associated depression of cell-mediated immunity.Rev.Infect.Dis. 6, 814–831 (1984).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Abram, M., Dorić, M. PrimaryListeria monocytogenes infection in gestating mice. Folia Microbiol 42, 65–71 (1997). https://doi.org/10.1007/BF02898648
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF02898648