Skip to main content
SpringerLink
Log in

Genetic epidemiological studies of longevity-associated mitochondrial DNA 5178 C/A polymorphism

  • Minireview Article
  • Published:
Environmental Health and Preventive Medicine Aims and scope

Abstract

Mitochondrial DNA 5178 cytosine/adenine (Mt5178 C/A) polymorphism is associated with longevity in the Japanese population, and the Mt5178A genotype may confer antiatherogenic advantages. Individuals with the Mt5178A genotype may be more resistant to adult-onset diseases, such as myocardial infarction, cerebrovascular diseases and type 2 diabetes, than those with the Mt5178C genotype. Moreover, Mt5178 C/A polymorphism has been reported to be associated with blood pressure, serum lipid levels, hematological parameters, intraocular pressure, serum protein fraction levels and serum electrolyte levels in healthy Japanese individuals. Differences in the influence of habitual drinking or habitual smoking on health status between the Mt5178C genotype and the Mt5178A genotype have been reported. The individual modification of drinking habits or smoking habits based on the genotyping of Mt5178 C/A may promote improved health and lead to the establishment of personalized prevention strategies for adult-onset diseases.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Willett WC. Balancing life-style and genomics research for disease prevention. Science 2002; 296: 695–698.

    Article  PubMed  CAS  Google Scholar 

  2. Tanaka M, Gong JS, Zhang J, Yoneda M, Yagi K. Mitochondrial genotype associated with longevity. Lancet. 1998; 351: 185–186.

    Article  PubMed  CAS  Google Scholar 

  3. Mukae S, Aoki S, Itoh S, Sato R, Nishio K, Iwata T, et al. Mitochondrial 5178A/C genotype is associated with acute myocardial infarction. Circ J. 2003; 67: 16–20.

    Article  PubMed  CAS  Google Scholar 

  4. Takagi K, Yamada Y, Gong JS, Sone T, Yokota M, Tanaka M. Association of a 5178C→A (Leu237Met) polymorphism in the mitochondrial DNA with a low prevalence of myocardial infarction in Japanese individuals. Atherosclerosis. 2004; 175: 281–286.

    Article  PubMed  CAS  Google Scholar 

  5. Ohkubo R, Nakagawa M, Ikeda K, Kodama T, Arimura K, Akiba S, et al. Cerebrovascular disorders and genetic polymorphisms: mitochondrial DNA5178C is predominant in cerebrovascular disorders. J Neurol Sci. 2002; 198: 31–35.

    Article  PubMed  CAS  Google Scholar 

  6. Wang D, Taniyama M, Suzuki Y, Katagiri T, Ban Y. Association of the mitochondrial DNA 5178A/C polymorphism with maternal inheritance and onset of type 2 diabetes in Japanese patients. Exp Clin Endocrinol Diabetes. 2001; 109: 361–364.

    Article  PubMed  CAS  Google Scholar 

  7. Matsunaga H, Tanaka Y, Tanaka M, Gong JS, Zhang J, Nomiyama T, et al. Antiatherogenic mitochondrial genotype in patients with type 2 diabetes. Diabetes Care 2001; 24: 500–503.

    Article  PubMed  CAS  Google Scholar 

  8. Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Sekine Y, Sekiguchi K, et al. Logevity-associated mitochondrial DNA 5178 A/C polymorphism and blood pressure in the Japanese population. J Hum Hypertens. 2004; 18: 41–45.

    Article  PubMed  CAS  Google Scholar 

  9. Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Sekine Y, Teruya K, et al. Association of the mitochondrial DNA 5178 A/C polymorphism with serum lipid levels in the Japanese population. Hum Genet. 2001: 109: 521–525.

    Article  PubMed  CAS  Google Scholar 

  10. Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Sekine Y. Sekiguchi K, et al. Longevity-associated mitochondrial DNA 5178 A/C polymorphism modulates effects of daily drinking and cigarette consumption on serum triglyceride levels in middle-aged Japanese men. Exp. Gerontol. 2003; 38: 1071–1076.

    Article  PubMed  CAS  Google Scholar 

  11. Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Makita R, Satoh M, et al. Overview of longevity-associated mitochondrial DNA 5178 C/A polymorphism and a discussion of its modulation of the effects of habitual smoking on serum total and LDL cholesterol levels in middle-aged Japanese men. In: Woods CR editors. Trends in DNA Research. New York: Nova Science (in press).

  12. Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Makita R, Satoh M et al. Interaction between longevity-associated mitochondrial DNA 5178 C/A polymorphism and cigarette smoking on hematological parameters in Japanese men. Arch Gerontol Geriatr. 2005; 40: 113–122.

    Article  PubMed  CAS  Google Scholar 

  13. Kokaze A, Yoshida M, Ishikawa M, Matsunaga N, Makita R, Satoh M, et al. Longevity-associated mitochondrial DNA 5178 A/C polymorphism is associated with intraocular pressure in Japanese men. Clin Experiment Ophthalmol. 2004; 32: 131–136.

    Article  PubMed  Google Scholar 

  14. Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Sekine Y, Teruya K, et al. Association of the longevity-associated mitochondrial DNA 5178 A/C polymorphism with serum protein fraction levels in healthy Japanese women. Exp Gerontol. 2002; 37: 931–936.

    Article  PubMed  CAS  Google Scholar 

  15. Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Sekine Y, Sekiguchi K, et al. Longevity-associated mitochondrial DNA 5178 A/C polymorphism influences effects of cigarette smoking on serum protein fraction levels in Japanese men. Mech Ageing Dev. 2003; 124: 765–770.

    Article  PubMed  CAS  Google Scholar 

  16. Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Makita R, Satoh M, et al. Longevity-associated NADH dehydrogenase subunit-2 polymorphism and serum electrolyte levels in middle-aged obese Japanese men. Mech Ageing Dev. 2005; 126: 705–709.

    Article  PubMed  Google Scholar 

  17. Yoshida M, Ishikawa M, Kokaze A, Sekine Y, Matsunaga N, Uchida Y, et al. Association of life-style with intraocular pressure in middle and older Japanese residents. Jpn J Ophthalmol. 2003; 47: 191–198.

    Article  PubMed  Google Scholar 

  18. Mori T, Sasaki J, Kawaguchi H, Handa K, Takada Y, Matsunaga A, et al. Serum glycoproteins and severity of coronary atherosclerosis. Am Heart J. 1995; 129: 234–238.

    Article  PubMed  CAS  Google Scholar 

  19. Iwao N, Iwao S, Kobayashi F, Tajima K, Tanaka M, Atsuta Y, et al. No association of the mitochondrial genotype (Mt5178A/C) with six cancers in a Japanese population. Asian Pac J Cancer Prev. 2003; 4: 331–336.

    PubMed  Google Scholar 

  20. Uchigata Y, Okada T, Gong JS, Yamada Y, Iwamoto Y, Tanaka M. A mitochondrial genotype associated with the development of autoimmune-related type 1 diabetes. Diabetes Care. 2002; 25: 2106.

    Article  PubMed  Google Scholar 

  21. Kato T, Kunugi H, Nakano S, Kato N. Association of bipolar disorder with the 5178 polymorphism in mitochondrial DNA. Am J Med Genet. 2000; 96: 182–186.

    Article  PubMed  CAS  Google Scholar 

  22. Aoyama M, Shidoji Y, Saimei M, Tsunawake N, Ichinose M. Phenotypic linkage between single-nucleotide polymorphisms of β-adrenergic receptor gene and NADH dehydrogenase subunit-2 gene, with special reference to eating behavior. Biochem Biophys Res Commun. 2003; 309: 261–265.

    Article  PubMed  CAS  Google Scholar 

  23. Lenaz G. Role of mitochondria in oxidative stress and ageing. Biochim Biophys Acta. 1998; 1366: 53–67.

    Article  PubMed  CAS  Google Scholar 

  24. Ballinger SW. Mitochondrial dysfunction in cardiovascular disease. Free Radic Biol Med. 2005; 38: 1278–1295.

    Article  PubMed  Google Scholar 

  25. Levine RL, Mosoni L, Berlett BS, Stadtman ER. Methionine residues as endogenous antioxidants in proteins. Proc Natl Acad Sci USA. 1996; 93: 15036–15040.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Public Health, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka-shi, 181-8611, Tokyo, Japan

    Akatsuki Kokaze

Authors
  1. Akatsuki Kokaze
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Akatsuki Kokaze.

Additional information

This article is based upon the research that was given Encouragement Award at the 74th Annual Meeting of the Japanese Society for Hygiene held in Tokyo, Japan on March 24–27, 2004.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kokaze, A. Genetic epidemiological studies of longevity-associated mitochondrial DNA 5178 C/A polymorphism. Environ Health Prev Med 10, 319–323 (2005). https://doi.org/10.1007/BF02898191

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02898191

Key words

Search

Navigation