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Depression as a risk factor for cardiac events in established coronary heart disease: A review of possible mechanisms

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Annals of Behavioral Medicine

Abstract

Depression is highly prevalent in patients with coronary heart disease (CHD) and is associated with excess medical morbidity and mortality. This article reviews the mechanisms which may mediate the relationship between depression and cardiac events in these patients. Research in this area is at an early stage of development. However, there is evidence that altered autonomic tone, smoking, hypertension, and, at least in older patients, poor adherence to the cardiac treatment regimen may be responsible for the adverse cardiac effects of depression.

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Authors and Affiliations

  1. Behavioral Medicine Center, Washington University School of Medicine, 216 South Kingshighway, 63110, St. Louis, MO

    Robert M. Carney, Kenneth E. Freedland, Michael W. Rich & Allan S. Jaffe

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  1. Robert M. Carney
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  2. Kenneth E. Freedland
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  3. Michael W. Rich
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  4. Allan S. Jaffe
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Additional information

Preparation of this manuscript was supported in part by Grant No. 2 R01 HL42427-04 from the National Heart, Blood, and Lung Institute, National Institutes of Health, Bethesda, Maryland, Robert M. Carney, Ph.D., Principal Investigator, and 5R01MH51419-02, from the National Institute of Mental Health, Kenneth E. Freedland, Ph.D., Principal Investigator.

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Carney, R.M., Freedland, K.E., Rich, M.W. et al. Depression as a risk factor for cardiac events in established coronary heart disease: A review of possible mechanisms. Ann Behav Med 17, 142–149 (1995). https://doi.org/10.1007/BF02895063

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