Skip to main content
SpringerLink
Log in

Placental and fetal manifestations of cytomegalovirus infection

  • Published:
Virchows Archiv B

Summary

Five cases of fetal cytomegalovirus infection are presented to illustrate the nature of the placental disease and the difference in fetal infectious sequelae. Widespread fetal infection occurred in very early dissemination of the virus with little inflammatory participation. In later stages both placental and fetal tissues sponsor an intense inflammatory infiltration with numerous plasma cells, and thrombotic phenomena are important sequelae. Viruria without recognizable disease was found in a newborn of a mother who suffered cervical virus infection in late pregnancy. It is emphasized that villous inflammatory lesions are characteristically associated with fetal CMV infection. Their identification can lead to early clarification of neonatal disease states.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Alford, C. A., Neva, F. A., Weiler, T. H.: Virologic and serologic studies on human products of conception after maternal rubella. New Engl. J. Med.271, 1275–1281 (1964)

    PubMed  Google Scholar 

  • Altshuler, G.: Placental villitis of unknown etiology: harbinger of serious disease ? A four months’ experience of nine cases. J. Reprod. Med.11, 215–222 (1973a)

    Google Scholar 

  • Altshuler, G.: Implications of two cases of human placental plasma cells ? Reports of cytomegalic inclusion disease in a thirteen week’s fetus and of ascending herpes infection of the newborn. Amer. J. Path.70, 18a (1973b)

    Google Scholar 

  • Altshuler, G., McAdams, A. J.: Cytomegalic inclusion disease of a nineteen-week fetus. Case report including a study of the placenta. Amer. J. Obstet. Gynec.111, 295–298 (1971)

    PubMed  CAS  Google Scholar 

  • Benirschke, K., Driscoll, S. G.: The pathology of the human placenta. In: Handbuch der speziellen pathologischen Anatomie und Histologie, Bd. VII/5. Berlin-Heidelberg-New York: Springer 1967

    Google Scholar 

  • Blanc, W. A.: Pathways of fetal and early neonatal infection. Viral placentitis, bacterial and fungal chorioamnionitis. J. Pediat.59, 473–496 (1961)

    Article  PubMed  CAS  Google Scholar 

  • Cochard, A.M., Le Tan-Vinh, LeLong, M.: Le placenta dans la cytomegalie congenital: étude anatomoclinique de 3 observations personelles. Arch. franç. Pédiat.20, 35–46 (1963)

    PubMed  CAS  Google Scholar 

  • Davis, L. E., Tweed, G. V., Stewart, J. A., Bernstein, M. T., Miller, G. L., Gravelle, C. R., Chin, T. D. Y.: Cytomegalovirus mononucleosis in a first trimester pregnant female with transmission to the fetus. Pediatrics48, 200–206 (1971)

    PubMed  CAS  Google Scholar 

  • Demian, S. D. E., Donnelly, W. H., Monif, G. R. G.: Coexistent congenital cytomegalovirus and toxoplasmosis in a stillborn. Amer. J. Dis. Child.125, 420–421 (1973)

    PubMed  CAS  Google Scholar 

  • Diosi, P., Babusceac, L., Nevinglovschi, O., Kun-Stoicu, G.: Cytomegalovirus infection associated with pregnancy. Lancet1967II, 1063–1066

  • Dollmann, A., Schmitz-Moormann, P.: Rekurrierende Plazentainsuffizienz durch villöse Plazentitis mit extremer fetaler Hypotrophie (Geburtsgewicht 1030 g and 1000 g am Termin). Geburtsh. u. Frauenheilk.32, 795–801 (1972)

    CAS  Google Scholar 

  • Embil, J. A., Ozere, R. L., Haidane, E. V.: Congenital cytomegalovirus infection in two siblings from consecutive pregnancies. J. Pediat.77, 417–421 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Feldman, R. A.: Cytomegalovirus infection during pregnancy. A prospective study and report of six cases. Amer. J. Dis. Child.117, 517–521 (1969)

    PubMed  CAS  Google Scholar 

  • Frenkel, J. K.: Cytomegalovirus infection and toxoplasma. Amer. J. Dis. Child.126, 860–861 (1973)

    PubMed  CAS  Google Scholar 

  • Goldman, R. L., Bank, R. W., Warner, N. E.: Cytomegalovirus infection of the cervix: an “incidental” finding of possible clinical significance. Obstet. and Gynec.34, 326–329 (1969)

    CAS  Google Scholar 

  • Goodman, M. L., Maher, E.: Four uncommon infections in Hodgkin’s disease. J. Amer. med. Ass.198, 1129 (1966)

    Article  CAS  Google Scholar 

  • Goranov, I., Gančev, S.: Fehlgeburt bei Zytomegalie. Zbl. Gynäk.85, 1037–1040 (1963)

    CAS  Google Scholar 

  • Hayes, K., Gibas, H.: Placental cytomegalovirus infection without fetal involvement following primary infection in pregnancy. J. Pediat.79, 401–405 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Jakubowicz, A.: Ueber protozoenartige Gebilde in Zellen verschiedener Organe des Menschen und ihr Zusammenhang mit angeborener Syphilis. Virchows Arch. path. Anat.276, 290–304 (1930)

    Article  Google Scholar 

  • Jindrák, K.: Die Zytomegalie in der Zervixschleimhaut einer Wöchnerin. Zbl. allg. Path. path. Anat.106, 255–258 (1964)

    Google Scholar 

  • Krech, V., Konjajev, Z., Jung, M.: Congenital cytomegalovirus infection in siblings from consecutive pregnancies. Helv. paediat. Acta26, 355–362 (1971)

    PubMed  CAS  Google Scholar 

  • Kumar, M. L., Nankervis, G. A., Gold, E.: Inapparent congenital cytomegalovirus infection. New Engl. J. Med.288, 1370–1372 (1973)

    PubMed  CAS  Google Scholar 

  • Lang, D. J., Kummer, J. F.: Demonstration of cytomegalovirus in semen. New Engl. J. Med.287, 756–758 (1972)

    PubMed  CAS  Google Scholar 

  • LeLong, M., LePage, F., LeTanVinh, Tournier, P., Chany, C.: Le virus de la maladie des inclusions cytomégaliques. Arch. franç. Pediat.17, 1–14 (1960)

    PubMed  CAS  Google Scholar 

  • LePage, F., Schramm, P.: Aspects histologiques du placenta et des membranes dans la maladie des inclusions cytomégaliques. Gynéc. et Obstét.57, 273–279 (1958)

    CAS  Google Scholar 

  • Monif, G. R. G., Dische, R. M.: Viral placentitis in congenital cytomegalovirus infection. Amer. J. clin. Path.58, 445–449 (1972)

    CAS  Google Scholar 

  • Monif, G. R. G., Egan, E. A., Held, B., Eitzmann, D. V.: The correlation of maternal cytomegalovirus infection during varying stages in gestation with neonatal involvement. J. Pediat.80, 17–20 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Monif, G. R. G., Sever, J. L., Schiff, G. M., Traub, R. G.: Isolation of rubella virus from products of conception. Amer. J. Obstet. Gynec.91, 1143–1146 (1965)

    PubMed  CAS  Google Scholar 

  • Quan, A., Strauss, L.: Congenital cytomegalie inclusion disease. Observations in a macerated fetus with congenital defect, including study of the placenta. Amer. J. Obstet. Gynec.83, 1240–1247 (1962)

    PubMed  CAS  Google Scholar 

  • Rosenstein, D. L., Navarette-Reyna, A.: Cytomegalic inclusion disease. Amer. J. Obstet. Gynec.89, 220–224 (1964)

    PubMed  CAS  Google Scholar 

  • Ross, L.: Incidental finding of cytomegalovirus inclusions in cervical glands. Amer. J. Obstet. Gynec.95, 956–958 (1966)

    PubMed  CAS  Google Scholar 

  • Seifert, G.: Pathologische Anatomie der Cytomegalie. Klin. Wschr.51, 533–540 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Sherer, W. T., Schreiner, R. L., Marshall, R. E., Barton, L. L.: Cytomegalovirus infection in a newborn dizygous twin. J. Pediat.81, 1161–1165 (1972)

    Article  Google Scholar 

  • Silverstein, A. M.: Ontogenesis of the immune response. In: Comparative aspects of reproductive failure (K. Benirschke, ed.), p. 392–412. Berlin-Heidelberg-New York: Springer 1967

    Google Scholar 

  • Simons, M. J.: Congenital rubella: An immunological paradox? Lancet1968 II, 1275–1278

    Article  Google Scholar 

  • Weller, T. H.: The cytomegaloviruses: ubiquitous agents with protean clinical manifestations. New Engl. J. Med.285, 203–214, 267–274 (1971)

    PubMed  CAS  Google Scholar 

  • Worth, W. A., Howard, H. L.: New features of inclusion disease of infancy. Amer. J. Path.26, 17–35 (1950)

    PubMed  Google Scholar 

  • Wyatt, J. P., Saxton, J., Lee, R. S., Pinkerton, H.: Generalized cytomegalic inclusion disease. J. Pediat.36, 271–294 (1950)

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Reproductive Medicine, Pediatrics and Pathology, University of California School of Medicine, La Jolla, California, USA

    K. Benirschke, G. R. Mendoza & P. L. Bazeley

  2. Department of Obstetrics and Gynecology, University of California School of Medicine, 92038, La Jolla, California, USA

    K. Benirschke

Authors
  1. K. Benirschke
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. R. Mendoza
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. L. Bazeley
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Benirschke, K., Mendoza, G.R. & Bazeley, P.L. Placental and fetal manifestations of cytomegalovirus infection. Virchows Arch B Cell Pathol 16, 121–139 (1974). https://doi.org/10.1007/BF02894070

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02894070

Keywords

Search

Navigation