Skip to main content
SpringerLink
Log in

Osteoclastoma-like giant cell tumor of the lung

  • Case Report
  • Published:
Pathology & Oncology Research

Abstract

The main components of an unusual form of lung tumor were osteoclast-like multinucleated giant cells and mononuclear stromal cells. Besides, scattered islands of moderately differentiated squamous cells also appeared. Both the mononuclear and the osteoclast-like giant cells reacted with antibodies against CD68 and vimentin, but did not react with antibodies against cytokeratin, EMA and CEA, or lysozyme and α-1-antitrypsin. The p53 and PCNA antigens were positive only in mononuclear cells and not the osteoclast-like giant cells, suggesting that mononuclear cells represent proliferating elements with histiocytic differentiation while osteoclast-like giant cells are stromal, presumably reactive components of the tumor.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Alguacil-Garcia A, Alonso A and Pettigrew NM: Sarcomatoid carcinoma (so-called pseudosarcoma) of the larynx simulating malignant giant cell tumor of soft parts. Am J Clin Pathol 82: 340–343, 1984.

    PubMed  CAS  Google Scholar 

  2. Alhanasou NA, Wells CA, Quinn J, Ferguson DP, Heryet A and McGee JO’D: The origin and nature of stromal osteoclastlike multinucleated giant cells in breast carcinoma: implications for tumour osteolysis and macrophage biology. Br J Cancer 59: 491–498, 1989.

    Google Scholar 

  3. Andreola S, Lombardi L, Seurelli A and Bersiga A: Osteoclastoma-like giant cell tumor of the liver. Case Report. Tumori 71: 615–620, 1985.

    CAS  Google Scholar 

  4. Andrew VC, Raitchev R and Nicolova D: Malignant osteoclastoma of the skin. Br J Dermatol 76: 40–44, 1964.

    Article  Google Scholar 

  5. Balogh K, Wolbarsht RL, Federman M and O’Hara CJ: Carcinoma of the parotid gland with osteoclast-like giant cells. Arch Pathol Lab Med 109: 756–761, 1985.

    PubMed  CAS  Google Scholar 

  6. Berendt RC, Shnitka TK, Wiens E, Manickavel V and Jewell LD: The osteoclast-type giant cell tumor of the pancreas. Arch Pathol Lab Med 111: 43–48, 1987.

    PubMed  CAS  Google Scholar 

  7. Cibull ML and Gray GF: Ultrastructure of osteoclastoma-like giant cell tumor of thyroid. Am J Surg Pathol 2: 401–405, 1978.

    PubMed  CAS  Google Scholar 

  8. Darby AJ, Papadaki L and Beilby JOW: An unusual leiomyosarcoma of the uterus containing osteoclast-like giant cells. Cancer 36: 495–504, 1975.

    Article  PubMed  CAS  Google Scholar 

  9. Dorney P: Osteoclastoma of the heart. Br Heart J 29: 276–278, 1967.

    Article  PubMed  CAS  Google Scholar 

  10. Eshun-Wilson K: Malignant giant cell tumor of the colon. Acta Pathol Microbiol Scand 81: 137–144. 1973.

    CAS  Google Scholar 

  11. Fsmaili JH, Hafez GR and Warner TFCS: Anaplastic carcinoma of the thyroid with osteoclast-like giant cells. Cancer 52: 2122–2128, 1983.

    Article  Google Scholar 

  12. Fusebi V, Martin SA, Govoni E and Rosai J: Giant cell tumor of major salivary gland: Report of three cases, one occuring in association with a malignant mixed tumor. Am J Clin Pathol 81: 666–675, 1984.

    Google Scholar 

  13. Factor SM, Biempica L, Ratner I, Ahuja KK and Biempica S: Carcinoma of the breast with multinucleated reactive stromal giant cells. Virchows Arch A 374: 1–12, 1977.

    CAS  Google Scholar 

  14. Fisher ER, Palekar AS, Gregorio RM and Paulson JD: Mucoepidermoid and squamous cell carcinomas of the breast with reference to squamous metaplasia and giant cell tumors. Am J Surg Pathol 7: 15–27, 1983.

    Article  PubMed  CAS  Google Scholar 

  15. Fisher H.-P, Altmannsberger M and Kracht J: Osteoclast-type giant cell tumour of the pancreas. Virchows Arch [A] Pathol Anat 412: 247–253, 1988.

    Article  Google Scholar 

  16. Fletcher CDM: Commentary. Malignant fibrous histiocytoma? Histopathology 11: 433–437, 1987.

    Article  PubMed  CAS  Google Scholar 

  17. Fran G, Dessy, Cherchi R and Cruz GS: Osteoclastoma-like giant cell tumor of the lung. Pathologica 81: 91–95, 1980.

    Google Scholar 

  18. Freund U: Pleomorphic giant cell tumor of the pancreas. Isr J Med Sci 9: 84–88, 1973.

    PubMed  CAS  Google Scholar 

  19. Gaal JM, Horvath E and Kovacs K: Ultrastructure of two cases of anaplastic giant cell tumor of the human thyroid gland. Cancer 35: 1273–1279, 1975.

    Article  PubMed  CAS  Google Scholar 

  20. Grosso LE and Gonzales JG: Stromal osteoclast-like giant cells in an adenosquamous carcinoma of the gallbladder. Hum Pathol 23: 703–706, 1992.

    Article  PubMed  CAS  Google Scholar 

  21. Guecion JGandFnzinger FM: Malignant giant cell tumor of soft parts. Cancer 29: 1518–1529, 1972.

    Article  Google Scholar 

  22. Guillan RA and McMahon J: Pleomorphic adenocarcinoma of the pancreas. Am J Gastroenterol 60: 379–386, 1973.

    PubMed  CAS  Google Scholar 

  23. Hofmann D, Jander R and Filler D: Osteoclastoma-like giant cell tumor of the lung. Thorac Cardiovasc Surg 28: 444–445, 1980.

    PubMed  CAS  Google Scholar 

  24. Holland R. and van Haelst UJGM: Mammary carcinoma with osteoclast-like giant cells: Additional observations on six cases. Cancer 53: 1963–1973, 1984.

    Article  PubMed  CAS  Google Scholar 

  25. Jalloh SS: Giant cell tumor (osteoclastoma) of the pancreas: An epithelial tumor probably of pancreatic acinar origin. J Clin Pathol 36: 1171–1175, 1983.

    Article  PubMed  CAS  Google Scholar 

  26. Jeffrey I, Crow J and Ellis BW: Osteoclast-type giant cell tumor of the pancreas. J Clin Pathol 36: 1165–1170, 1983.

    Article  PubMed  CAS  Google Scholar 

  27. Kinntra K, Ohnishi Y, Morishita H, Amezaki M and Irikura H: Giant cell tumor of the kidney. Virchows Atch Pathol Anat 398: 357–365, 1983.

    Article  Google Scholar 

  28. Kuroda M, Oka T, Horiuchi H, Ishida T, Machinami R andHebisawa A: Giant cell tumor of the lung: an autopsy case report with immunohistochemical observations. Pathol Int 44: 158–163, 1994.

    Article  PubMed  CAS  Google Scholar 

  29. Kuwano H, Sonoda T, Hashimoto H and Enjoji M: Hepatocellular carcinoma with osteoclast-like giant cells. Cancer 54: 837–842, 1984.

    Article  PubMed  CAS  Google Scholar 

  30. Fadanvi M, Traganos F and Huvos AG: Benign metastasizing giant cell tumor of bone: A DNA flow cytometric study. Cancer 64: 1525–26, 1989.

    Google Scholar 

  31. Levin A, Rywlin AM and Tachmes P: Carcinoma of the breast with stromal epulis-like giant cells. South Med J 74: 889–891, 1981.

    PubMed  CAS  Google Scholar 

  32. Love GL and Daroca PJ: Bronchogenic sarcomaloid squamous cell carcinoma with osteoclast-like giant cells. Hum Pathol 14: 1004–1006, 1983.

    Article  PubMed  CAS  Google Scholar 

  33. Lucas JG, Sharma HM and O’Toole RV: Unusual giant cell tumor arising in a male breast. Hum Pathol 12: 840–844, 1981.

    Article  PubMed  CAS  Google Scholar 

  34. Munoz PA, Rao MS and Reddy JK: Osteoclastomalike giant cell tumor of the liver. Cancer 47: 771–779, 1980.

    Article  Google Scholar 

  35. Nakahashi H, Tsuyenoshi M, Ishida T, Minagawa S, Owaki Y, Momii S and Eimoto T: Undifferentiated carcinoma of the lung with osteoclast-like giant cells. Jpn J Surg 17: 199–203, 1987.

    Article  PubMed  CAS  Google Scholar 

  36. Nishiyama RH, Dunn EL and Thompson NW: Anaplastic spindle cell and giant cell tumors of the thyroid gland. Cancer 30: 113–127, 1972.

    Article  PubMed  CAS  Google Scholar 

  37. Oyasu R, Battifora HA, Buckingham WB and Hidvegi D: Metaplastic squamous cell carcinoma of bronchus simulating giant cell tumor of bone. Cancer 39: 1119–1128, 1977.

    Article  PubMed  CAS  Google Scholar 

  38. Pettinato G, Manivel JC, Picone A, Petrella G and Insabato L: Alveolar variant of infiltrating lobular carcinoma of the breast with stromal osteoclast-like giant cells. Pathol Res Pract 185: 388–394, 1989.

    PubMed  CAS  Google Scholar 

  39. Posen JA: Giant cell tumor of the pancreas of the osteoclastic type associated with a mucous secreting cystadenocarcinoma. Hum Pathol 12: 944–947, 1981.

    Article  PubMed  CAS  Google Scholar 

  40. Robinson L, Damjenov I and Brezina P: Multinucleated giant cell neoplasm of pancreas. Arch Pathol Lab Med 101: 590–593, 1977.

    PubMed  CAS  Google Scholar 

  41. Rosai J: Carcinoma of pancreas simulating giant cell tumor of bone: Electron microscopic evidence of its acinar cell origin. Cancer 22: 333–344, 1968.

    Article  PubMed  CAS  Google Scholar 

  42. Salm R and Sissons HA: Giant cell tumor of soft tissues. J Pathol 107: 27–39, 1972.

    Article  PubMed  CAS  Google Scholar 

  43. Silverberg SG and DeGiorgi LS: Osteoclastoma-like giant cell tumor of the thyroid. Cancer 31: 621–625, 1973.

    Article  PubMed  CAS  Google Scholar 

  44. Sugano J, Nagao K, Kondo Y and Nabeshima S: Cytologic and ultrastructural studies of a rare breast carcinoma with osteoclast-like giant cells. Cancer 52: 74–78, 1983.

    Article  PubMed  CAS  Google Scholar 

  45. Trepeta RW, Mathur B, Lagin S and LiVolsi V: Giant cell tumor (“osteoclastoma”) of the pancreas, a tumor of epithelial origin. Cancer 48: 2022–2028, 1981.

    Article  PubMed  CAS  Google Scholar 

  46. Tschang TP, Garza-Garza R and Kissani JM: Pleomorphic carcinoma of the pancreas. Cancer 39: 2114–2126, 1977.

    Article  PubMed  CAS  Google Scholar 

  47. Veliath AJ, Sankaran V and Aurora AL: Ovarian giant cell tumor with cystadenocarcinoma. Arch Pathol 99: 488–491, 1975.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Human and Experimental Tumor Pathology, National Institute of Oncology, Ráth György u. 7–9, 1122, Budapest, Hungary

    Zsolt Orosz

  2. Department of Molecular Pathology, National Institute of Oncology, Budapest

    Erika Tóth

  3. Department of Pathology, Kaposi Mór Hospital, Kaposvár, Hungary

    Anna Viski

Authors
  1. Zsolt Orosz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Erika Tóth
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Anna Viski
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Orosz, Z., Tóth, E. & Viski, A. Osteoclastoma-like giant cell tumor of the lung. Pathol. Oncol. Res. 2, 84–88 (1996). https://doi.org/10.1007/BF02893957

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02893957

Key words

Search

Navigation