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HLA class II polymorphism: Protective or risk factors to breast cancer in Tunisia?

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Pathology & Oncology Research

Abstract

HLA system plays a key role in the tumor cells’ escape from immune surveillance. Herein is the first report on the correlation of the susceptibility to breast cancer with HLA class II markers in Tunisia. Molecular typing of HLA-DRB1 and -DQB1 loci was undertaken for 70 Tunisian female patients. Comparison of allele and haplotype distribution between patients and 70 female control subjects reveals a negative association between HLA-DRB1*07-DQB1*02 and the incidence of breast cancer in the Tunisian population. (Pathology Oncology Research Vol 12, No 2, 79–81)

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Authors and Affiliations

  1. Laboratory of Molecular Genetics, Immunology and Biotechnology, Department of Biology, Faculty of Sciences of Tunis, ElManar University, 1060, Tunis, Tunisia

    Amal Baccar Harrath, Besma Yacoubi Loueslati, Wafa Troudi, Syrine Sedkaoui & Amel Ben Ammar Elgaaied

  2. Tunisian Center of Blood Transfusion, Tunisia

    Slama Hmida, Amel Dridi & Afef Jridi

  3. Salah Azeiz Oncology Institute, Tunisia

    Farhat Ben Ayed & Khaled Ben Rhomdhane

Authors
  1. Amal Baccar Harrath
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  2. Besma Yacoubi Loueslati
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  3. Wafa Troudi
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  4. Slama Hmida
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  5. Syrine Sedkaoui
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  6. Amel Dridi
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  7. Afef Jridi
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  8. Farhat Ben Ayed
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  9. Khaled Ben Rhomdhane
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  10. Amel Ben Ammar Elgaaied
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Correspondence to Amal Baccar Harrath.

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Harrath, A.B., Loueslati, B.Y., Troudi, W. et al. HLA class II polymorphism: Protective or risk factors to breast cancer in Tunisia?. Pathol. Oncol. Res. 12, 79–81 (2006). https://doi.org/10.1007/BF02893448

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  • DOI: https://doi.org/10.1007/BF02893448

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