Summary
Alterations in surfactant-secreting type II pneumocytes, detectable by 24 h following exposure, are the most rapidly manifested toxic effects of lung irradiation. These studies follow the morphological and biochemical changes in the surfactant system which lead to pathologically detectable radiation pneumonitis by 18 weeks post-irradiation, and suggest the possibility that early analysis of surfactant changes may have predictive value for later pulmonary sequelae to irradiation.
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References
Bligh EG, Dyer WJ (1959) A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37: 911–917
Chen PS, Toribara TY, Warner H (1956) Microdetermination of phosphorus. Anal Chem 28: 1756–1958
Field SB, Hornsey S (1974) Damage to mouse lung with neutrons and x-rays. Eur J Cancer 10: 621–627
Heppleston, AG, Styles JA (1967) Activity of a macrophage factor in collagen formation by silica. Nature (Lond) 214: 521–522
Mason RJ, Nellenbogen J, Clements JA (1976) Isolation of disaturated phosphatidylcholine with osmium tetroxide. J Lipid Res 17: 281–284
Moosavi H, McDonald S, Rubin P, Cooper RA, Jr, Stuard ID, Penney DP (1977) Early radiation dose-response in lung: An ultrastructural study. Intern J Radiat Oncol Biol Phys 2: 921–931
Penney DP, Rubin P (1976) Specific early fine structural changes in the lung following irradiation. Intern J Radiat Oncol Biol Phys 1 (Suppl 1): 40
Penney DP, Rubin P (1977) Specific early fine structural changes in the lung following irradiation. Intern J Radiat Oncol Biol Phys 2: 1123–1132
Penney DP, Shapiro D, Rubin P, Finkelstein J, Averill K (1980) Effects of irradiation on alveolar type II pneumocytes. Anat Rec 196: 145–146A
Phillips, TL, Benak S, Ross G (1972) Ultrastructural and cellular effects of ionizing irradiation. In: Varth JM (ed) Front Radiat Ther Onc, Vol 6. University Park Press, Baltimore, pp 31–43
Rooney SA, Wai-Lee TS, Gobran L, Motoyama EK (1976) Phospholipid content, composition and biosynthesis during fetal lung development in the rabbit. Biochim Biophys Acta 431: 447–458
Rubin P, Shapiro DL, Finkelstein JN, Penney DP (1980) The early release of surfactant following lung irradiation of alveolar type II cells. Intern J Radiat Oncol Biol Phys 6: 75–77
Rubin P, Casarett GW (1968) Clinical radiation pathology, vol 1. WB Saunders, Philadelphia
Siemann DW, Kochanski K (1981) Combinations of radiation and misonidazole in a murine lung tumor model. Radiat Res (in press)
Shapiro D, Finkelstein J, Penney D, Siemann D, Rubin P (1981) Sequential effects of irradiation on the pulmonary surfactant system. Intern J Radiat Onc Biol Phys (submitted)
Travis EL (1980) The sequence of histological changes in mouse lungs after single doses of x-rays. Intern J Radiat Oncol Biol Phys 6: 345–347
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Penney, D.P., Shapiro, D.L., Rubin, P. et al. Effects of radiation on the mouse lung and potential induction of radiation pneumonitis. Virchows Archiv B Cell Pathol 37, 327–336 (1981). https://doi.org/10.1007/BF02892581
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DOI: https://doi.org/10.1007/BF02892581