Summary
We observed the changes of parameters of coagulation and fibrinolytic system in order to understand the clinical implication of these variations in type I diabetic patients. Subjects consisted of 22 patients with type I diabetes mellitus and 25 healthy controls. Compared with the control, activated partial thromboplastin time, prothrombin time were shortened in the patients. The diabetic subjects also displayed higher levels of D-dimer, serum fibrin degradation products, median concentrations of fibrinogen (3. 99 vs 2. 96 g/L,P<0. 01) and von Willebrand factor (149 % vs 87 %,P<0.01). Levels of antithrombin activity or antigen were not different from control values. Simple linear regression analysis revealed a negative correlation between antithrombin activity and fast blood glucose. Diabetic patients with vascular complications had significantly higher levels of fibrinogen and D-dimer than those without diabetic angiopathy. Our data demonstrated that patients with type I diabetes mellitus had a hypercoagulable state. We believed the activation of coagulation might contribute to the vascular complications in diabetics.
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Junbin, H., Wenning, W., Guizhi, D. et al. Variations and clinical significance of coagulation and fibrinolysis parameters in patients with diabetes mellitus. Current Medical Science 18, 233–235 (1998). https://doi.org/10.1007/BF02886480
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DOI: https://doi.org/10.1007/BF02886480