Abstract
The reaction of formaldehyde and diamides of 1,2-diamines in acetic acid containing a trace of hydrochloric acid was found to give 1,3-diacyl derivatives of imidazolidine in high yield. The similar reaction of formaldehyde and diamides of 1,3-propylenediamine gave high yields of 1,3-diacylhexahydropyrimidines. Attempts to extend this reaction to other aldehydes than formaldehyde failed, as did attempts to condense formaldehyde with a diamide which would give a four-membered or seven-membered ring system, the diamide being recovered unchanged in each instance. Twenty-two new compounds were prepared and characterized.
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Mod, R.R., Magne, F.C. & Sumrell, G. 1,3-Diacyl derivatives of imidazolidine and hexahydropyrimidine: I. Preparation by novel method and characterization. J. Am. Oil Chem. Soc. 48, 254–256 (1971). https://doi.org/10.1007/BF02883764
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DOI: https://doi.org/10.1007/BF02883764