Abstract
The red quinone C20H14O8 (mp 322–324), named bikaverin was isolated from mycelium ofGibberella fujikuroi. Bikaverin is specifically effective againstLeishmania brasiliensis while is not effective against other protozoa, bacteria and fungi. For production of bikaverin in a submerged culture the most convenient media are those with a natural source of nitrogen (corn-steep liquor, soyabean meal) in which the content of bikaverin ranged from 1.0 to 1.7% of dry weight of mycelium.
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Balan, J., Fuska, J., Kuhr, I. et al. Bikaverin, an antibiotic fromGibberella fujikuroi, effective againstLeishmania brasiliensis . Folia Microbiol 15, 479–484 (1970). https://doi.org/10.1007/BF02880192
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DOI: https://doi.org/10.1007/BF02880192