Abstract
We investigated the distribution of Y-chromosome haplotype using 19 Y-SNPs in Han Chinese populations from 22 provinces of China. Our data indicate distinctive patterns of Y chromosome between southern and northern Han Chinese populations. The southern populations are much more polymorphic than northern populations. The latter has only a subset of the southern haplotypes. This result confirms the genetic difference observed between southern and northern ethnic populations in East Asia. It supports the hypothesis that the first settlement of modern humans of African origin occurred in the southern part of East Asia during the last Ice Age, and a northward migration led to the peopling of northern China.
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References
Cann, R. L., Stoneking, M., Wilson, A. C., Mitochondria DNA and human evolution, Nature, 1987, 325: 31–36.
Vigilant, L., Stoneking, M., Harpending, H. et al., African populations and the evolution of human mitochondrial DNA, Science, 1997, 253: 1503–1507.
Cavalli-Sforza, L. L., Piazza, M. P., The History and Geography of Human Genes, Princeton: Princeton University Press, 1994.
Brooks, A. S., Wood, B., Paleoanthropology, The Chinese side of the story, Nature, 1990, 344: 288–289.
Li, T., Etler, D. A., New middle Pleistocene hominid crania from Yunxian in China, Nature, 1992, 357: 404–407.
Wu, X. Z., Poirier, F. E., Human Evolution in China, Oxford: Oxford University Press, 1995.
Etler, D. A., The fossil evidence for human evolution in Asia, Annu. Rev. Anthropol., 1996, 25: 275–301.
Wolpoff, M. H., Interpretations of multiregional evolution, Science, 1996, 274: 704–707.
Stringer, C. B., Andrew, P., Genetic and fossil evidence for the origin of modern humans, Science, 1988, 239: 1263–1268.
Wilson, A. C., Cann, R. L., The recent African genesis of humans, Scientific American, 1992, (4): 68–75.
Weng, Z., Yuan, Y., Du, R., Analysis of the genetic structure of human populations in China, Acta Anthropol. Sin. (in Chinese)1989, 8: 261–268.
Zhao, T., Zhang, G., Zhu, Y. et al., The distribution of immunoglobulin Gm allotypes in forty Chinese populations, Acta Anthropol. Sin. (in Chinese), 1986, 6: 1–8.
Chu, J. Y., Huang, W., Kuang, S. Q. et al., Genetic relationship of populations in China, Proc. Natl. Acad. Sci., 1998, 95: 11763–11768.
Jobling, M. A., Tyler-Smith, C., Fathers and sons: the Y chromosome and human evolution, Trends in Genetics, 1995, 11: 449–455.
Oefner, P. J., Underhill, P. A., Comparative DNA sequencing by denaturing high-performance liquid chromatography (DHPLC), Am. J. Hum. Genet., 1995, 57: A266.
Oefner, P. J., Underhill, P. A., DNA mutation detection using denaturing high performance liquid chromatography (DHPLC), Current Protocols in Human Genetics, Supplement, 1998, 19(7): 10.1–7.10.12.
Underhill, P. A., Jin, L., Zemans, R. et al., A pre-Columbian human Y chromosome-specific transition and its implications for human evolution, Proc. Natl. Acad. Sci., 1996, USA 93: 196–200.
Underhill, P. A., Jin, L., Lin, A. A. et al., Detection of numerous Y chromosome biallelic polymorphisms by denaturing high-performance liquid chromatography, Genome Research, 1997, 7: 996–1005.
Vollrath, D. S., Vollrath, D., Foote, S. et al., The human Y chromosome: A 43-interval map based on naturally occurring deletions, Science, 1992, 258: 52–59.
Underhill, P. A., Jin, L., Lin, A. A. et al., An African origin of human Y-chromosomes, Program and Abstract, 1997 Annual Meeting of The American Society of Human Genetics, Am. J. Hum. Genet, 1997, 61 (supplement): A18.
Kayser, M., Caglia, A., Corach, D. et al., Evaluation of Y-chromosomal STRs: a multicenter study, Int. J. Legal Med., 1997, 110: 125–133.
Su, B., Xiao, J. H., Underhill, P. et al., Y-chromosome evidence for a northward migration of modern humans into eastern Asia during the last ice age, Am. J. Hum. Genet., 1999, 6: 1718–1724.
Ballinger, S. W., Schurr, T. G., Torroni, A. et al., Southeast Asian mitochondrial DNA analysis reveals genetic continuity of ancient mongoloid migrations, Genetics, 1992, 130: 139–152.
Heyer, E., Puymirat, J., Dieltjes, P. et al., Estimating Y chromosome specific microsatellite mutation frequencies using deep rooting pedigrees, Human Molecular Genetics, 1997, 6: 799–803.
Bianchi, N. O., Catanesi, C. L., Bailliet, G. et al., Characterization of ancestral and derived Y-chromosomal haplotypes of New World native populations, Am. J. Hum. Genet, 1998, 63: 1862–1871.
Turner, II C. G., Shifting continuity: modern human origin, in The Origin and Past of Modern Humans as Viewed From DNA(eds. Brenner, S., Hanihara, K.), New York: World Sciencific, 1993, 216–243.
Vasil’ev, S. A., The upper Paleolithic of northern Asia, Current Anthropology, 1993, 34: 82–92.
Brown, P., Recent human evolution in East Asia and Australia, Philos. Trans. R. Soc., 1992, 337(1280): 235–242.
Swisher, C. C., 3rd, Rink, W. J., Anton, S. C. et al., LatestHomo erectus of Java: potential contemporaneity withHomo sapiens in Southeast Asia, Science, 1996, 274: 1870–1874.
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Ke, Y., Su, B., Xiao, J. et al. Y-chromosome haplotype distribution in Han Chinese populations and modern human origin in East Asians. Sci. China Ser. C.-Life Sci. 44, 225–232 (2001). https://doi.org/10.1007/BF02879329
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DOI: https://doi.org/10.1007/BF02879329