Skip to main content
SpringerLink
Log in

The complete genome of Enterovirus 71 China strain

  • Published:
Science in China Series C: Life Sciences Aims and scope Submit manuscript

Abstract

Five overlapping clones covering the full genome of Enterovirus 71 China strain SHZH98 were obtained and then the sequences were determined by the chain termination method. It showed that the full length of EV71 SHZH98 genome (not including Poly A tail) is 7408 bp. There are some diversities on the lengths and sequences of 5′ UTR and 3′ UTR between SHZH98 and the other EV71 strains. In P1 capsid region, which is closely associated with viral immunogenicity, EV71 strain SHZH98 shares the highest homology with Taiwan strains; but in P2 and P3 non-structural gene regions there are higher identities with Coxsakievirus A16 and EV71 strains MS, BrCr than with Taiwan strains. Phylogenetic tree constructed by structural gene region indicates that China strain SHZH98 has a closer relationship with Taiwan strains, however, in the non-coding region it has a closer relationship with Coxsakievirus A16, EV71 strains MS and BrCr. EV71 China strain was analyzed at the molecular level. The results will contribute to the basic study on enteroviruses and the EV71 prevention in China.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Jin, Qi, Medical Molecular Virology (in Chinese), Beijing: Science Press, 2001.

    Google Scholar 

  2. McMinn, P., Stratov, I., Dowse, G., Enterovirus 71 outbreak in Western Australia associated with acute flaccid paralysis, Preliminary report, Commun. Dis. Intell., 1999, 23(7): 199.

    CAS  Google Scholar 

  3. Ho, M., Chen, E. R., Hsu, K. H. et al., An epidemic of Enterovirus 71 infection in Taiwan, The New England Journal of Medicine, 1999, 341(13): 929.

    Article  PubMed  CAS  Google Scholar 

  4. He Yaqing, Yang Fan, Li Chengliang et al., Identification of EV71 isolates from hand, foot and mouth disease cases in ShenZhen, Chinese Journal of Experimental and Clinical Virology (in Chinese), 1999, 1: 112.

    Google Scholar 

  5. Landry, M. L., Fonseca, S. N. S., Cohen, S. et al., Fatal enterovirus type 71 infection: rapid detection and diagnostic pitfalls, Pediatr. Infect. Dis. J., 1995, 14: 1095.

    Article  PubMed  CAS  Google Scholar 

  6. Brown, B. A., Pallansch, M. A., Complete nucleotide sequence of enterovirus 71 is distinct from poliovirus, Virus Res., 1995, 39: 195.

    Article  PubMed  CAS  Google Scholar 

  7. Brown, B. A., Oberste, M. S., Alexander, J. P. Jr., Molecular epidemiology and evolution of Enterovirus 71 strains isolated from 1970 to 1998, J. Virol., 1999, 73(12): 9969.

    PubMed  CAS  Google Scholar 

  8. Ishimaru, Y., Nakano, S., Yamaoka, K. et al., Outbreaks of hand, foot, and mouth disease by Enterovirus 71, Arch. Dis. Child., 1980, 55: 583.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. State Key Laboratory for Molecular Virology and Genetic Engineering, 100052, Beijing, China

    Fan Yang, Qi Jin, Yaqing He, Liangcheng Li & Yunde Hou

Authors
  1. Fan Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Qi Jin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yaqing He
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Liangcheng Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yunde Hou
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Qi Jin.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yang, F., Jin, Q., He, Y. et al. The complete genome of Enterovirus 71 China strain. Sci. China Ser. C.-Life Sci. 44, 178–183 (2001). https://doi.org/10.1007/BF02879323

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02879323

Keywords

Search

Navigation