Summary
30 ml of aluminum hydroxide gel, administered 15 minutes before a single oral dose of aureomycin, markedly depressed the serum aureomycin levels in 10 subjects. The simultaneous use of these two drugs is contraindicated. 30 ml of carmethose given in the same manner had no demonstrable effect on the aureomycin level of the serum, and effectively diminished the gastrointestinal disturbances frequently occurring with aureomycin therapy.
Amphojel adsorbs aureomycin in vitro. It does not destroy or inactivate the latter, but it seems to hold it firmly, not permitting intestinal absorption. Carmethose does not adsorb aureomycin in vitro, and does not interfere with intestinal absorption.
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Aided by the Nelson Morris Fund. The Departments are in part supported by the Michale Reese Recharch Foundation
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Greenspan, R., Maclean, H., Milzer, A. et al. Antacids and Aureomycin. Amer. Jour. Dig. Dis. 18, 35–37 (1951). https://doi.org/10.1007/BF02876255
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DOI: https://doi.org/10.1007/BF02876255