Abstract
Serum malondialdehyde was measured in sixty-one falciparum malaria cases, which include thirty uncomplicated, and thirty-one complicated with acute renal failure. Twenty-six healthy individuals were also studied as controls. Serum malondialdehyde level was found to be significantly elevated in falciparum malaria induced acute renal failure cases when compared with uncomplicated falciparum malaria (p<0.001) and healthy controls (p<0.001). A positive correlation with the raised urea, creatinine and bilirubin levels were significant (r=0.62, p<0.025; r=0.65, p<0.05 and r=0.72, p<0.001 respectively) indicating the severity of complication with rise of lipid peroxides in falciparum malaria induced acute renal failure cases.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Sitprija, V. (1988) Nephrology forum: Nephropathy in falciparum malaria. Kidney Int. 34, 867–877.
Boonpucknavig, V. and Sitprija, V. (1979) Renal disease in acute Plasmodium falciparum infection. Kidney Int. 16, 44.
Etkin, N.L. and Eaton, J.W. (1975) Erythrocyte structure and function. (Brown G.I. Ed.) New York Liss, 219–232.
Decamps-Latscha, B., Nunel-Fabini, E., Karbinis, A. and Druilhe, P. (1987) Generation of reactive oxygen species in whole blood from parasites with acute falciparum malaria. Parasite Immunol. 9, 275–279.
Clark, L.A. and Hunt, N.H. (1983) Infect. Immun. 39, 1–6.
Das, B.S., Patnaik, J.K., Mohanty, S., Sathpathy, S.K., Mishra, S.K., Mohanty, D. and Bose, T.K. (1988) Enhanced lipid peroxidation in Plasmodium falciparum malaria. Ind J. Clin. Biochem. 3, 150.
Baud, L. and Aradaillow, R. (1986) Reactive oxygen species: Production and role in kidney. Am. J. Physiol. 251, F, 765–776.
Green, E.L. and Paller, M.S. (1991) Oxygen free radicals in ARF. Minor Electrolyte Metab. 17, 124–132.
Shah, S.V. (1989) Role of oxygen reactive metabolites in experimental glomerular disease. Kidney Int. 35, 1039–1106.
Rath, R.N., Panigrahi, N., Das, B.K. and Das, P.K. (1991) Lipid peroxidation in acute falciparum malaria. Ind. J. Med. Res. 93, 303–305.
Mohan, K., Ganguly, N.K., Dubey, M.L. and Mahajan, R.C. (1992) Oxidative damage of erythrocytes infected with Plasmodium falciparum: Anin vitro study. Ann. Hematol. 65(3), 131–134.
Das, B.S., Patnaik, J.K., Mohanty, S., Mishra, S.K., Mohanty, D., Sathpathy, S.K. and Bose, T.K. (1993) Plasma antioxidants and lipid peroxidation products in falciparum malaria. Am. J. Trop. Med. Hyg. 49(6), 720–725.
Sharma, A.K., Arora, M., Gupta, R., Makkad, R.K. and Gupta, H.P. (1998) Free Radicals in acute renal failure due to falciparum malaria. Indian J. Nephrol. 8, 101–103.
Joannidis, M., Bonn, G. and Pfaller, W. (1989) Lipid peroxidation. An initial event in experimental acute renal failure. Renal Physiol. Biochem. 12, 47–55.
Dioudis, C., Papageorgiou, G., Iliadis, S., Zilidis, C. and Alivanis, P. (1996) Lipid peroxidation after acute renal ischemia and reperfusion in rats, the effects of trimetazidine renal failure. Renal Fail. 18(4), 545–557.
Matusushima, H., Yonemura, K., Ohishi, K. and Hishida, A. (1998) The role of free radicals in cisplatin-induced acute renal failure in rats. J. Lab. Clin. Med. 131(6), 518–526.
Soejima, A., Suzuki, M., Ishizuka, S., Fuknoka, T. and Nagasawa, T. (1994) Lipid peroxidation and tubular disorder in experimental ARF. Nippon Jinzo Gakhai Shri. 36(7), 800–804.
Walker, P.D. and Shan, S.V. (1988) Evidence suggesting a role for hydroxyl radical in gentamicin induced ARF in rats. J. Clin. Invest. 81(2), 334–342.
Mishra, N.C., Lalitha, R. and Sharma, A. (1994) Oxidative stress and malaria infected erythrocytes. Indian J. Malariology 31, 77–87.
Odel, G.B., Natzschka, J.C. and Storey, G.N.B. (1967) Bilirubin nephropathy in the Gunn strain rat. Am. J. Physiol. 221, 931–935.
Baum, M., Sterling, G.A. and Dawson, J.L. (1969) Further study into obstructive jaundice and ischemic renal damage. Br. Med. J. 2, 229–232.
Aoyagi, T. and Lowenstem, L.M. (1969) The effect of bile acid and renal ischemia on renal funtion. J. Lab. Clin. Med. 71, 686–690.
Marks, D.B., Marks, A.D. and Smith, C.M. (1996) Basic Medical Biochemistry: A Clinical Approach. Williams and Wilkins, p. 334.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nanda, R., Mishra, P.K., Das, U.K. et al. Evaluating role of oxidative stress in determining the pathogenesis of falciparum malaria induced acute renal failure. Indian J Clin Biochem 19, 93–96 (2004). https://doi.org/10.1007/BF02872399
Issue Date:
DOI: https://doi.org/10.1007/BF02872399