Skip to main content
Log in

Iron store and free radicals in thalassemia

  • Published:
Indian Journal of Clinical Biochemistry Aims and scope Submit manuscript

Abstract

Hyper-ferrous state is the result of multiple transfusions, whereby the iron excess in such conditions may be toxic to the organism. Patients suffering from thalassemia receive multiple transfusions. In the eastern part of India, both β0-thalassemia and heterozygous Eβ-thalassemia occur. This paper expresses the hyper-ferrous state, leading to iron overload in these two conditions and also reports the increased generation of free radicals, consequent to the iron overload.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Conrad, M.E. (1998). Introduction: Iron overloading disorder and iron regulation. Seminars in Hematol. 35 (1), 1–4

    CAS  Google Scholar 

  2. Halberg, L. (1981). Bioavailability of dietary iron. Ann. Rev. Nutr. 1 (1), 123–125.

    Article  Google Scholar 

  3. McCord, J.M. (1992). Superoxide production and human disease. In Jesaitis, A. and Dratz, E. (eds.): Molecular basis of oxidative damage by leukocytes. Boca Raton. FL. CRC, pp. 225–239.

    Google Scholar 

  4. McCord, J.M. (1974). Free radicais and inflammation: Protection of synovial fluid by superoxide dismutase. Science 185, 159–163.

    Article  Google Scholar 

  5. Halliwell, B. and Gutteridge, J.M.C. (1992). Biologically relevant metal ion-dependent hydroxyl radical generation-An update. FEBS Lett. 307, 108–112.

    Article  PubMed  CAS  Google Scholar 

  6. Gutteridge, J.M.C., Rowley, D.A. and Halliwell, B. (1982). Superoxide dependent formation of hydroxyl radicals and lipid peroxidation in the presence of iron salts. Biochem. J. 206, 605–609.

    PubMed  CAS  Google Scholar 

  7. Biomond, P., Swaak, A.J. Bemdorff, C.M.et al. (1986). Superoxide dependent and independent mechanisms of iron mobilization from ferritin by xanthine oxidase implications for oxygen-free radical-induced tissue destruction during ischaemia and inflammation. Biochem. J. 239, 169–173.

    Google Scholar 

  8. Biemond, P. van Eijk, H.G., Swaak, A.J.G.et al.. (1984). Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes. Possible mechanism in inflammation diseases. J. Clin. Invest. 73, 1576–1579.

    Article  PubMed  CAS  Google Scholar 

  9. van Assendelft, O.W. and Lewis, S.M. (1991). Recommended method for the determination of the haemoglobin concentration of blood. WHO Docum. Lab. 8 fold Rev. 1.

  10. Drabkin, D.L. and Austin, J.H. (1932). Spectrophotometric studies: Spectrophotometric constant for common hemoglobin derivatives in human, dog and rabbit blood. J. Biol. Chem. 98, 719–733.

    CAS  Google Scholar 

  11. Ohkwa, M., Ohighi, N. and Yagi, K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analyt. Biochem. 95, 357–358.

    Google Scholar 

  12. Chatterjee, C.C. (1983). Human Physiology. Volume II. Medical Allied Agency, India pp. 10–11.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to K. Goswami.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Goswami, K., Ghosh, S., Bandyopadhyay, M. et al. Iron store and free radicals in thalassemia. Indian J Clin Biochem 20, 192–194 (2005). https://doi.org/10.1007/BF02867427

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02867427

Key words

Navigation