Summary
The expression of hypoxia inducible factor-1 alpha (HIF-1α) and its relationship to apoptosis in tissues around cerebral bleeding loci was studied. The expression of HIF-1α and apoptosis in 37 samples of tissues around cerebral bleeding loci and 9 samples of normal cerebral tissues was assessed by immunohistochemical straining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling methods. In 37 tissue samples around cerebral bleeding loci, the positive rate of the HIF 1α expression was 40.6%. Especially in the patients with amount of bleeding >60 ml, the positive rate (88.9%) of the HIF-1α expression was significantly higher than those with the amount of blceding ranging from 30, 45 ml or 45, 60 ml (P<0.05). The expression of HIF-1α was increased as the amount of bleeding and operative time increased (P<0.05). There existed a positive correlation between HIF-1α labeling index and apoptosis index (n=12,r=0.56,P<0.01). These results suggested that the expression of HIF-1α was closely related with the time of hemorrhage and the amount of bleeding, and could induce the apoptosis of neurons.
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ZHU Suiqiang, male, born in 1964. Associate Professor
This project was supported by a grant from Clinical Subject Key Program Foundation of Ministry of Public Health (No. 97070241).
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Suiqiang, Z., Zhouping, T., Shougang, G. et al. Experimental study on the expression of HIF-1α and its relationship to apoptosis in tissues around cerebral bleeding loci. Current Medical Science 24, 373–375 (2004). https://doi.org/10.1007/BF02861871
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DOI: https://doi.org/10.1007/BF02861871