Summary
To study the expression of peroxisome proliferator-activated receptor-γ(PPAR-γ) in lung cancer cells, and to testify if the PPAR-γ agonists can inhibit human lung cancer cell growth through induction of apoptosis, PPAR-γ was detected in two lung cancer cell lines by RT-PCR and immunohistochemistry, the inhibition of human lung cancer cell growth was investigated by MTT and cell counts, and the apoptosis was assessed by TUNEL. The results showed that: (1) PPAR-γ expressed on two lung cancer cell lines; (2) PPAR-γ activated by ligands could inhibit human lung cancer cell growth remarkably; (3) PPAR-γ agonists could induce apoptosis to inhibit lung cancer cell growth. It was concluded that PPAR-γ expressed in lung cancer cell can be activated by ligands and can inhibit lung cancer cell growth through induction of apoptosis.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Fajas L, Debril M B, Auwerx Jet al. Peroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesis. J Mol Endocrinol, 2001, 27(1):1
Tsubouchi Y, Sano H, Kawahito Yet al. Inhibition of human lung cancer cell growth by the peroxisome proliferator-activated receptor-gamma agonists through induction of apoptosis. Biochem Biophys Res Commun, 2000, 270(2):400
Eibl G, Wente M N, Reber H Aet al. Peroxisome proliferator-activated receptor gamma induces pancreatic cancer cell apoptosis. Biochem Biophys Res Commun, 2001, 287(2):522
Jiang W G, Redern A, Bryce R Pet al. Peroxisome proliferator activated receptor-gamma (PPAR-gamma) mediates the action of gamma linolenic acid in breast cancer cells. Prostaglandins Leukot Essent Fatty Acids, 2000, 62(2):119
Kitamura S, Miyazaki Y, Shinomura Yet al. Peroxisome proliferator-activated receptor gamma induces growth arrest and differentiation markers of human colon cancer cells. Jpn J Cancer Res, 1999, 90(1):75
Theocharis S, Kanelli H, Politi Eet al. Expression of peroxisome proliferator activated receptor-gamma in non-small cell lung carcinoma: correlation with histological type and grade. Lung Cancer, 2002, 36(3):249
Wijnhoven B P, Lindstedt E W, Abbou Met al. Molecular genetic analysis of the von Hippel-Lindau and human peroxisome proliferator-activated receptor gamma tumor-suppressor genes in adenocarcinomas of the gastroesophageal junction. Int J Cancer, 2001, 94(6):891
Wood I. Pro-inflammatory mechanisms of a nonsteroidal anti-inflammatory drug. Trends Endocrinol Metab, 2002, 13(2):53
Satoh T, Toyoda M, Hoshino Het al. Activation of peroxisome proliferator-activated receptor-gamma stimulates the growth arrest and DNA-damage inducible 153 gene in non-small cell lung carcinoma cells. Oncogene, 2002, 21(14):2171
Inoue K, Kawahito Y, Tsubouchi Yet al. Expression of peroxisome proliferator-activated receptor (PPAR)-gamma in human lung cancer. Anticancer Res, 2001, 21 (4A):2471
Author information
Authors and Affiliations
Additional information
Zhang Min, female, born in 1977, Doctor in Charge
This project was supported by a grant from Natural Sciences Foundation of Hubei Province (Serial No. 98J102).
Rights and permissions
About this article
Cite this article
Min, Z., Ping, Z., Ming, B. et al. Peroxisome proliferator-activated receptor-γ activated by ligands can inhibit human lung cancer cell growth through induction of apoptosis. Current Medical Science 23, 138–140 (2003). https://doi.org/10.1007/BF02859937
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02859937