Summary
The relationship between 3 polymorphisms sites [interleulin-4 (IL-4), IL-4 receptor (IL-4R) α chain and activation-induced cytidine deaminase (AICDA)] and adult allergic asthma in China was studied. By using case-control method, DNA and clinical data were obtained from allergic asthmatic patients and compared with those in the control subjects. The subjects were genotyped for the IL-4 C-589T promoter polymorphism, the IL-4R α chain Q576R and the AICDA C8408T by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The results showed that the IL-4 C-589T was not associated with adult allergic asthma in China. However, the IL-4R α chain 576R/R and AICDA 8408T/T frequency was significantly increased in allergic asthma group as compared with that in the control group [odd ratio (OR)=3.797 and 9.127, respectively;P<0.01)] and was correlated with the increased plasma total IgE. These data suggested that the IL-4R α chain 576R/R and AICDA 8408T/T genotypes confer genetic susceptibility to adult allergic asthma in China.
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Cui Tianpen, male, born in 1967, Assistant Researcher
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Tianpen, C., Lin, W., Jianmin, W. et al. Polymorphisms of IL-4, IL-4Rα, and AICDA genes in adult allergic asthma. Current Medical Science 23, 134–137 (2003). https://doi.org/10.1007/BF02859936
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DOI: https://doi.org/10.1007/BF02859936