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Isolation of hepatic drug metabolism inhibitors from the Rhizomes ofCurcuma zedoaria

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Abstract

The methanolic extract of the Rhizome ofCurcuma zedoaria exhibited a significant prolongation of hexobarbital (HB)-induced hypnosis. Through liquid chromatography of an ether soluble fraction, monitoring by bioassay, three sesquiterpenes, germacrone(A), curzerenone(B) and germacrone epoxide(C) were isolated as active constituents. A single treatment (100–200mg/kg, i.p.) of each compound showed not only a significant prolongation of HB-induced sleeping time but also a significant inhibition of amino-pyrine N-demethylase activity in mice, and further exhibited a typical type I binding spectra with oxidized rat hepatic cytochrome P-450 induced by phenobarbital. All of the compounds provoked a sleep episode at a subhypnotic dose of HB, implying that they possess CNS depressant properties.

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Authors and Affiliations

  1. Natural Products Research Institute, Seoul National University, 110-460, Seoul, Korea

    Kuk Hyun Shin, Ok Nam Kim & Won Sick Woo

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  1. Kuk Hyun Shin
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  2. Ok Nam Kim
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  3. Won Sick Woo
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Additional information

Part 13 in the series “Studies on crude drugs acting on drug-metabolizing enzyme”. For part 12 see ref. 1

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Hyun Shin, K., Nam Kim, O. & Sick Woo, W. Isolation of hepatic drug metabolism inhibitors from the Rhizomes ofCurcuma zedoaria . Arch. Pharm. Res. 12, 196–200 (1989). https://doi.org/10.1007/BF02855554

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  • DOI: https://doi.org/10.1007/BF02855554

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