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Modulating inhibitory ligand-gated ion channels

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Abstract

The glycine and γ-aminobutyric acid receptors (GlyR and GABAAR, respectively) are the major inhibitory neurotransmitter-gated receptors in the central nervous system of animals. Given the important role of these receptors in neuronal inhibition, they are prime targets of many therapeutic agents and are the object of intense studies aimed at correlating their structure and function. In this review, the structure and dynamics of these and other homologous members of the nicotinicoid superfamily are described. The modulatory actions of the major biological macromolecules that bind and allosterically affect these receptors are also discussed.

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  1. Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, 15261, Pittsburgh, PA

    Michael Cascio

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Published: May 26, 2006

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Cascio, M. Modulating inhibitory ligand-gated ion channels. AAPS J 8, 40 (2006). https://doi.org/10.1007/BF02854906

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