Abstract
The direct effects of dexmedetomidine on isolated gravid rat myometrium were investigated in this in vitro study; such effects may have clinical repercussions in the administration of anesthesia to obstetric patients. Samples of myometrium were taken from 12 gravid rats. Myometrial strips were dissected microscopically and mounted on the myograph at a resting tension of 1 gin bath that contained Krebs solution. After spontaneous contractions of the myometrium had been steadily established, increasing concentrations of dexmedetomidine were added to baths via micropipette, and the effects of these additions were recorded via myograph. Dexmedetomidine in vitro caused a significant increase in the amplitude, frequency, and area under the curve of myometrial contractions in a dose-dependent manner. Results of this study demonstrate that dexmedetomidine increases spontaneous contractions in rat myometrium; however, further investigation is needed to clarify the usefulness of dexmedetomidine in the administration of obstetric anesthesia.
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References
Naftalin NJ, Phear WPC, Goldberg AH. Halothane and isometric contractions of isolated pregnant rat myometrium.Anesthesiology. 1975; 42: 458–463.
Naftalin NJ, McKay DM, Phear WPC, Goldberg AH. The effects of halothane on pregnant and nonpregnant human myometrium.Anesthesiology. 1977; 46: 15–19.
Karsli B, Kaya T, Cetin A. Effects of intravenous anesthetic agents on pregnant myometrium.Pol J Pharmacol. 1999; 51: 505–510.
Dogru K, Dalgic H, Yildiz K, Sezer Z, Madenoglu H. The direct depressant effects of desflurane and sevoflurane on spontaneous contractions of isolated gravid rat myometrium.Int J Obstet Anesth. 2003; 12: 74–78.
Aantaa R, Kallio A, Virtanen R. Dexmedetomidine, a novel α2-adrenergic agonist. A review of its pharmacodynamic characteristics.Drugs Fut. 1993; 18: 49–56.
Paech MJ, Banks SL, Gurrin LC, Yeo ST, Pavy TJ. A randomized, double-blinded trial of subarachnoid bupivacaine and fentanyl, with or without clonidine, for combined spinal/epidural analgesia during labor.Anesth Analg. 2002; 95: 396–401.
Eisenach JC, Castro MI, Dewan DM, Rose JC. Epidural clonidine analgesia in obstetrics: sheep studies.Anesthesiology. 1989; 70: 51–56.
Jacobs MM, Hayashida D, Roberts JM. Human myometrial adrenergic receptor by [3H] dihydroergocryptine binding.Am J Obstet Gynecol. 1985; 152: 680–684.
Arici G, Karsli B, Kayacan N, Akar M. The effects of bupivacaine, ropivacaine and mepivacaine on the contractility of rat myometrium.Int J Obstet Anesth. 2004; 13: 95–98.
Ebert TJ, Hall JE, Barney JA, Toni DU, Colinco MD. The effects of increasing plasma concentrations of dexmedetomidine in humans.Anesthesiology. 2000; 93: 382–394.
Sia AT, Kwek K, Yeo GS. The in vitro effects of clonidine and dexmedetomidine on human myometrium.Int J Obstet Anesth. 2005; 14: 104–107.
Kitazawa T, Maezono Y, Taneike T. The mechanisms of alpha(2)-adrenoceptor agonist-induced contraction in longitudinal muscle of the porcine uterus.Eur J Pharmacol. 2000; 390: 185–195.
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Karaman, S., Evren, V., Firat, V. et al. The effects of dexmedetomidine on spontaneous contractions of isolated gravid rat myometrium. Adv Therapy 23, 238–243 (2006). https://doi.org/10.1007/BF02850129
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DOI: https://doi.org/10.1007/BF02850129