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Increased antioxidant capacity in healthy volunteers taking a mixture of oral antioxidants versus vitamin C or E supplementation

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Abstract

The objectives of this study were (1) to evaluate the capacity of human plasma that had been obtained from healthy adult volunteers before and after they ingested vitamin E or C to inhibit induced lipoperoxidation in vitro (antioxidant capacity of plasma [ACP]), and (2) to compare the efficiency of these vitamins with that of a commercial mixture of antioxidant vitamins, cofactors, and minerals (MAOx). Seventy-nine healthy individuals between 19 and 23 y of age were randomly assigned to 1 of 4 groups. Each received a daily dose of antioxidants for 7 d: vitamin C (n=18; 500 mg), vitamin E (n=21; 400 IU), vitamins C and E (n=19), or MAOx (n=21; 1.2 g). ACP and plasma malondialdehyde were measured at 4 and 24 h and 7 d. ACP increased significantly (P<.05) in all 4 groups within 4 h of antioxidant intake, and this effect was sustained throughout supplementation. Plasma ACP increased significantly over basal values in the group taking MAOx; relative increases were 42%, 44%, and 55% at 4 h, 24 h, and 7 d, respectively (P<.001). Smaller increases in plasma ACP were observed in the vitamin C group (25%, 32%, and 36%) and, specifically, in the vitamin E group (17%, 24%, and 28%) (P<.05). The mixture of vitamins and minerals was comparatively more efficient than vitamin C or E alone, presumably because MAOx contains various antioxidant compounds with different redox potentials, leading to the possible development of chain reactions.

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Authors and Affiliations

  1. Postgraduate Department, Medical School of High Studies, National Politechnical Institute, USA

    Eleazar Lara-Padilla MD, MSc, Alexander Kormanovski PhD, Pindaro Alvarez Grave MD, MSc, Ivonne Maria Olivares-Corichi MSc, PhD & Roberto Medina Santillan MD, PhD

  2. Inorganic Biochemistry Laboratory, Department of Research and Environmental Medicine, National Institute of Respiratory Medicine, Mexico City, Mexico

    Juan José Hicks MD, PhD

Authors
  1. Eleazar Lara-Padilla MD, MSc
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  2. Alexander Kormanovski PhD
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  3. Pindaro Alvarez Grave MD, MSc
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  4. Ivonne Maria Olivares-Corichi MSc, PhD
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  5. Roberto Medina Santillan MD, PhD
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  6. Juan José Hicks MD, PhD
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Correspondence to Juan José Hicks MD, PhD.

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Lara-Padilla, E., Kormanovski, A., Grave, P.A. et al. Increased antioxidant capacity in healthy volunteers taking a mixture of oral antioxidants versus vitamin C or E supplementation. Adv Therapy 24, 50–59 (2007). https://doi.org/10.1007/BF02849992

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