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Cholesterol-lowering effects of a new isolated soy protein with high levels of nondenaturated protein in hypercholesterolemic patients

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Abstract

This study was undertaken to compare the effects on plasma cholesterol concentration of a new isolated soy protein in which the protein structure is kept in its native, nondenaturated form (verum 1) versus a conventional isolated soy protein (verum 2) and milk protein (placebo). This prospective, randomized, double-blind, placebo-controlled study was conducted in an outpatient clinical study center in Berlin, Germany. Over 8 wk, 120 patients (total cholesterol, 5.2–7.8 mmol/L) were given verum 1, verum 2, or placebo at a dosage of 25 g protein daily. At the end of the treatment period, total cholesterol levels were significantly reduced by 10.7% in the verum 1 group compared with placebo (P < .001), and levels were reduced by 5.8% in the verum 2 group (P=.008). The difference between the 2 verum groups was statistically significant (P=.008). Low-density lipoprotein cholesterol levels were significantly reduced with nondenaturated isolated soy protein only: levels were reduced by 9.4% in the verum 1 group (P=.002) and by 4.9% in the verum 2 group (P=.107). Again, the difference between the verum groups was significant (P=.05). The results of this study confirm that supplementation with isolated soy protein can lead to significant reductions in plasma concentrations of total and low-density lipoprotein cholesterol. These reductions are significantly more pronounced with an isolated soy protein that maintains the native protein structure than with a commercially available reference isolated soy protein.

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Authors and Affiliations

  1. c/o A Sjoholm, VO Internmedicin, Sodersjukhuset Karolinska Institute, 118 83, Stockholm, Sweden

    L. H. Hoie MD, M. Guldstrand MD, PhD & A. Sjoholm MD, PhD (Prof)

  2. Phytopharm Research, Berlin, Germany

    H. J. Graubaum PhD & J. Gruenwald PhD

  3. Institute for Nutritional Science, University of Potsdam, Potsdam, Germany

    H. J. F. Zunft PhD (Prof)

  4. German Institute of Human Nutrition, Bergholz-Rehbruecke, Germany

    H. J. F. Zunft PhD (Prof) & W. Lueder PhD

Authors
  1. L. H. Hoie MD
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  2. M. Guldstrand MD, PhD
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  3. A. Sjoholm MD, PhD
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  4. H. J. Graubaum PhD
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  5. J. Gruenwald PhD
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  6. H. J. F. Zunft PhD
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  7. W. Lueder PhD
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Correspondence to L. H. Hoie MD.

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Hoie, L.H., Guldstrand, M., Sjoholm, A. et al. Cholesterol-lowering effects of a new isolated soy protein with high levels of nondenaturated protein in hypercholesterolemic patients. Adv Therapy 24, 439–447 (2007). https://doi.org/10.1007/BF02849913

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