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Multicenter, randomized, controlled trial of heat-killedLactobacillus acidophilus LB in patients with chronic diarrhea

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Abstract

Chronic diarrhea is a common bowel disorder; disturbance of intestinal microorganisms may play a role in its pathogenesis. This study assessed the clinical efficacy of lyophilized, heat-killedLactobacillus acidophilus LB versus living lactobacilli in the treatment of chronic diarrhea. One hundred thirty-seven patients with chronic diarrhea were randomly allocated to receive either a 4-week course of 2 capsules of Lacteol® Fort twice a day (Lacteol group, 69 patients) or a 4-week course of 5 chewable tablets of Lacidophilin® three times a day (Lacidophilin group, 64 patients). The frequency of stools was recorded quantitatively, and semiquantitative parameters such as stool consistency, abdominal pain, distortion, and feeling of incomplete evacuation were evaluated. At the second and fourth week of treatment, mean bowel frequency was significantly lower in the Lacteol group than in the Lacidophilin group (1.88±1.24 vs 2.64±1.12, 1.39±0.92 vs 2.19±1.05; P<.05). At the end of the treatment, the clinical symptoms were markedly improved in the Lacteol group, indicating thatL. acidophilus LB is more effective than living lactobacilli in the treatment of chronic diarrhea.

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Authors and Affiliations

  1. Shanghai Institute of Digestive Disease, Shanghai Renji Hospital, 145 Shan-Dong Zhong Road, 200001, Shanghai, China

    Shy-Dong Xiao MD

  2. Shanghai Second Medical University Ruijin Hospital, China

    Zhong De Zhang MD, Hong Lu MD & Shi Hu Jiang MD

  3. Shanghai Fudan University Zhongshan Hospital, China

    Hou Yu Liu MD

  4. Shanghai Huadong Hospital, China

    Geng Sheng Wang MD

  5. Chinese Second Military Medical University Changhai Hospital, China

    Guo Ming Xu MD

  6. Chinese Second Military Medical University Changzheng Hospital, China

    Zhong Bing Zhang MD

  7. Shanghai Fudan University Huashan Hospital, China

    Geng Jin Lin MD

  8. Shanghai First People’s Hospital, Shanghai, China

    Guo Liang Wang MD

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  1. Shy-Dong Xiao MD
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  2. Zhong De Zhang MD
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Xiao, SD., De Zhang, Z., Lu, H. et al. Multicenter, randomized, controlled trial of heat-killedLactobacillus acidophilus LB in patients with chronic diarrhea. Adv Therapy 20, 253–260 (2003). https://doi.org/10.1007/BF02849854

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