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Hemostatic effects of Microporous Polysaccharide Hemosphere® in a rat model with severe femoral artery bleeding

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Abstract

An appropriate hemostatic dressing for prehospital use should lower mortality due to uncontrolled hemorrhage. In this study, the investigators explored the hemostatic effects of Microporous Polysaccharide Hemosphere® (MPH) applied in a rat model with severe femoral artery bleeding. Twelve rats were randomly assigned to MPH and control groups: The femoral artery of each rat was pierced to initiate bleeding. Then, 0.25 g MPH was poured into the bleeding site. A 200-g scale weight was placed over the bleeding site for 30 sec. At 30-sec intervals, the scale weight was removed, and hemostasis was assessed visually. After 30 sec, if the bleeding had ceased, the test was scored and checked as “passed at 30 sec.” If the bleeding had not stopped, the same procedures were repeated a maximum of 3 times. If hemostasis could not be achieved even after the third application, the test was scored as failed. The same sequence of procedures was repeated for the control group without use of MPH and with only standard compression. Application of MPH resulted in complete control of bleeding in 2 of 6, 4 of 6, and 6 of 6 rats at 30, 60, and 90 sec, respectively. In the control group, however, hemostasis could not be achieved in all 6 rats, even at 90 sec. The difference between the 2 groups was statistically significant (P=.007). Application of MPH and compression with a scale weight significantly decreased the time of hemostasis in the rat model with femoral arterial bleeding.

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Authors and Affiliations

  1. Department of Emergency Medicine, University of Dokuz Eylul, School of Medicine, Izmir, Turkey

    Gurkan Ersoy MD (Assist Prof, General Surgeon) & M. Firat Kaynak MD (Emergency Physician, Attending Physician)

  2. Department of Animal Research Center, University of Dokuz Eylul, School of Medicine, Turkey

    Osman Yilmaz MV (Prof)

  3. Alsancak State Hospital, University of Dokuz Eylul, School of Medicine, Izmir, Turkey

    Ulkumen Rodoplu MD

  4. Department of Anesthesiology and Reanimation, University of Dokuz Eylul, School of Medicine, Izmir, Turkey

    Fikret Maltepe MD (Assist Prof) & Necati Gokmen MD (Assoc Prof)

Authors
  1. Gurkan Ersoy MD
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  2. M. Firat Kaynak MD
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  3. Osman Yilmaz MV
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  4. Ulkumen Rodoplu MD
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  5. Fikret Maltepe MD
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  6. Necati Gokmen MD
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Correspondence to Gurkan Ersoy MD.

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Ersoy, G., Kaynak, M.F., Yilmaz, O. et al. Hemostatic effects of Microporous Polysaccharide Hemosphere® in a rat model with severe femoral artery bleeding. Adv Therapy 24, 485–492 (2007). https://doi.org/10.1007/BF02848770

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  • DOI: https://doi.org/10.1007/BF02848770

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