Abstract
Incontinence disorders are an important group of problems that clinicians manage in children and adolescents. This paper reviews the physiology of micturition, the epidemiology of enuresis, etiologic concepts of incontinence disorders, a general clinical approach to enuretic patients, laboratory evaluation and general principles of management. Neurological and nephrological concepts of enuresis are emphasized in this discussion.
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References
Greydanus DE and Torres AD. Genitourinary and renal disorders. In: Stamford CT.Adolescent Medicine, 3rd Ed. Appleton and Lange, 1997: 220–241.
Ghoniem GM and Sakr MA. Bladder dysfunction syndromes. State of the Art Reviews.Adolesc Med 1996; 7 (1): 35–46.
Rushton HG. Nocturnal enuresis. Epidemiology, evaluation and currently available treatment options.J Pediatr 1989; 114 (Suppl): 691–696.
Rushton HG. Wetting and functional voiding disorders.Urol Clin N Am 1995; 22 (1): 75–94.
Wein AJ. pathophysiology and categorization of voiding dysfunction. In:Campbell's Urology, 7th edn, Philadelphia, PA: W.B. Saunders Company, 1998; 27: 917–926.
Steers WD. Physiology and pharmacology of the bladder and urethra. In:Campbell's Urology, 7th edn. Philadelphia, PA: W.B. Saunders Company, 1998; 26: 870–915.
S. Roy Meadow. Nocturnal enuresis. In: Edelman Jr (ed).Pediatric Kidney Disease, 2nd Edition, 1992; pp. 2015–2020.
Garg BP. Disorders of micturition and defecation. In: Swaiman K (ed).Pediatric Neurology Principles and Practice. St. Louis, Mo: CV Mosby Company, 1994; 20: 271–283.
Byrd RS, Weitzman M, Lanphaear NEet al. Bed wetting in US children: Epidemiology and related behaviour problems.Pediatrics 1996; 98: 414–19.
Bloom DA, Faerber G and Bomalaski MD. Urinary incontinence in girls. Evaluation, treatment, and its place in the standard model of voiding dysfunctions in children.Urol Clin N Amer 1995; 22 (3): 521–538.
Bloom DA, Pohl J and Norgaard JP. Comments on enuresis, particularly the nocturnal type.Scand J Urol Nephrol Suppl 1994; 163: 7–13.
Robson WLM, Leung AKC and Bloom DA. Daytime wetting in childhood.Clin Pediatr 1996; 31 (2): 91–98.
Gimpel GA, Worzak WJ, Kuhn MR, Walburn NJ. Clinical perspective in primary nocturnal enuresis.Clin Pediatr 1998; 37 (1): 23–29.
Norgaard JP, Rittig S, Djurbuus JC. Nocturnal enuresis, an approach to treatment based on pathogenesis.J Pediatr 1989; 114 (suppl): 705.
Wan J and Greenfield S. Enuresis and common voiding abnormalities.Pediatric Clin N Amer 1997; 44 (5): 1117–1131.
Kass EJ, Diokno AC, Montealegre A. Enuresis: Principles of management and result of treatment.J Urol 1979; 121: 794–706.
Jalmask H. Nocturnal enuresis: Basic facts and new horizons.Eur Urol 1998; 33 (Suppl 3): 53–7.
Eiberg H, Berendt I and Mohr J. Assignment of dominant inherited nocturnal enuresis (EUR 1) to chromosome 137.Nature Genetics 1995; 10: 354–356.
Moffatt MS. Nocturnal enuresis: Psychologic implications of treatment and nontreatment.J Pediatr 1989; 114: 697.
Jalmask H. Nocturnal enuresis in childhood.Nord Med 1998; 113 (1): 13–15.
Aikawa T, Kasahara T and Uchiyama M. The arginine-vasopressin secretion profile of children with primary nocturnal enuresis.Eur Urol 1998; 33 (suppl) 3: 41–4.
The Arginine Vasopressin Secretion Profile in children with primary nocturnal enuresis.Eur Urol 1998; 33: Suppl 3, 41–44.
Kuznetsova AA, Natochin YV and Papayan AV. Osmo-regulatory function of the kidney in enuretic children.Scand J Urol Nephrol 1998; 32: 132–7.
Neveus T, Lackgren G, Stenberg Aet al. Sleep and night-time behaviour of enuretics and non-enuretics.Br J Urol 1998; 81 (Suppl) 3: 67–71.
Watanabe H. Nocturnal enuresis.Eur Urol 1998; 33 (suppl) 3: 2–11.
Kawauchi A, Imada N, Tanaka Yet al. Effects of systemic treatment based on overnight simultaneous monitoring of electroencephalogram and cystometry.Eur Urol. 1998; 33: suppl 3: pp 58–61.
Chandra M. Nocturnal enuresis in children.Curr Opin Pediatr 1998; 10 (2): 167–173.
Loening-Baucke V. Urinary incontinence and urinary tract infections and their resolution with treatment of chronic constipation in children.Pediatrics 1997; 100 (2): 228–232.
Fergusson DM and Horwood LJ. Nocturnal enuresis and behavioural problems in adolescence: A 15-year longitudinal study.Pediatrics 1994; 94: 662–668.
Sher PK, Reinberg Y, Yuri Reinberg. Successful treatment of giggle incontinence with methylphenidate.J Urol 1996; 156: 656–658.
Schulpen TWJ, Hirusing RA. Going Dutch in nocturnal enuresis.Acta Pediatr 1996; 85: 199–203.
Moffatt MEK, Harlos S, Kirshen AJet al. Desmopressin acetate and nocturnal enuresis: How much do we know?Pediatrics 1993; 92: 420.
Stenberg A and Lackgren G. Desmopressin tablets in the treatment of severe nocturnal enuresis in adolescents.Pediatrics 1994; 94: 841–6.
Chiozza ML, Plebani M. Evaluation of antidiuretic hormone before and after long term treatment with desmopressin in a group of children.Br J Urol 1998; Suppl 3: 53–55.
Donaghue MB, Latimer ME, Pillsbury HL, Hertzog L. Hyponatremic seizures in a child using desmopressin for nocturnal enuresis.Arch Pediatr Adoles Med 1998; 152 (3): 290–292.
Schwab M and Ruder J. Hyponatremia and cerebral convulsion due to DDAVP administration in patients with enuresis nocturnia or urinary concentrating testing.Eur J Pediatr 1997; 156 (8): 668.
Robson JP, Norguard NK, Leung C. Hyponatremia in patients with nocturnal enuresis treated with DDAVP.Eur J Ped 1996; 155: 959–962.
Miranda B, Bertraud JE Arano. Efficacy of oxybutynin chloride in children with vesicoureteral reflux and detrusor instability.Ann Eur Pediatr 1997; 47 (3): 251–257.
Hinman F. Non-neurogenic bladder (the Hinman syndrome) fifteen years later.J Urol 1991; 136: 769.
Odersson AF, Jorgensen TM. Changes in nocturnal bladder capacity during treatment with the bell and pad for monosymptomatic nocturnal enuresis.J Urol 1998; 160 (1): 166–169.
Friman PC, Handwerk ML, Swearer SMet al. Do children with primary nocturnal enuresis have clinically significant behaviour problems?Arch Pediatr Adolesc Med 1998; 152: 537–9.
Hagglof B, Andren O, Bergstrom Eet al. Self-esteem in children with nocturnal enuresis and urinary incontinence: Improvement of self-esteem after treatment.Eur Urol. 1998; 33 (suppl) 3: 16–19.
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Greydanus, D.E., Torres, A.D., O'Donnell, D.M. et al. Enuresis: Current concepts. Indian J Pediatr 66, 425–438 (1999). https://doi.org/10.1007/BF02845537
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DOI: https://doi.org/10.1007/BF02845537