Abstract
Objective: To observe the effect of Xiaoyu Zhixue tablet (XYZXT) on the expression of platelet membrane glycoproteins in patients with hemorrhagic thrombopathy, and to explore its possible mechanism. Methods; The total of 148 patients with hemorrhagic thrombopathy were randomly divided into two groups, the traditional Chinese medicicne (TCM) group (n = 98) treated with XYZXT and the Western medicine (WM) group (n = 50) treated with adrenosin, vitamins C, K and P, both for 6 months. The therapeutic effect and the recovery rate of platelet aggregation in the two groups were observed. And platelet membrane glycoprotein (GP) Ib/IX, GPII b/IIIa complexes, GPIb, GPIIb, GPIIIa and P-selectin were analyzed by flow cytometry in both groups before and after treatment and also in 34 normal healthy subjects.Results: The total effective rate of hemostasis was 89.8% in TCM group and 54.0% in the WM group (X 2=45.83,P<0.01), and the recovery rate of platelet aggregation was 72.4% and 4.0% respectively (X 2 = 62.06,P<0.01). The fluorescence intensity of GP I b/IX, GP II b/III a complexes, GPIb, GP IIIa and P-selectin were lower in both groups before treatment than those in the healthy subjects. Expression of above-mentioned marks was elevated in TCM group after 6 months’ therapy, which was insignificantly different as compared with the healthy subjects (P>0.05) and higher than those in the WM group (P<0.05).Conclusion: One of the mechanisms in treating hemorrhagic thrombopathy with XYZXT is that it could regulate the expression of GP I b/IX, GPII b/IIIa complexes, GP I b, GPIIIa and P-selectin at the level of receptor protein.
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References
Shen D, Ling ZS, chief editors. Clinical hemorrhagiopathy. Beijing: Science and Technology Liter Press, 1996: 43–45.
Shen D, Zhu M, Wang AL, et al. Study on ultrastructure of platelets of hemorrhagic thrombopathy patients. Hua-zhong Med J 1997;21(2): 75–76.
Shen D, Shen L, Wang AL, et al. Clinical observation of Xiaoyu Zhixue tablet in treating 104 cases of idiopathic multifocal hemorrhage complicated with platelet aggregation defect. ChinJ Integr Tradit West Med 1997; 17(5): 280–282.
Shen D, Zhu M, Wang AL, et al. Study on platelet aggregation function in idiopathic multifocal hemorrhagic patients. J Thromb Hemost 1996;3(4): 145–147.
Yang LH, Shen D, Wang AL, et al. Applying flow cytometry to examine glycoprotein change of platelet membrane of idiopathic thrombopathy patients. Chin J Physical Med 1997;19(9): 165–167.
Vorchheimer DA, Badimon JJ, Fuster V. Platelet glycoprotein II b/ III a receptor antagonists in cardiovascular disease. JAMA 1999;281: 1407–1414.
Nurden AT, Cazes E, Bihour C, et al. Confirmation that GP I b/IX complexes have a reduced surface distribution on platelets activated by thrombin and TRAP-14-mer peptide. Br Haematol 1995; 90: 645–654.
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Supported by the National Natural Science Foundation of China (No. 30171194)
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Lin, S., Di, S., Lan, G. et al. Effect of Xiaoyu Zhixue tablet on expression of platelet membrane glycoproteins in patients with hemorrhagic thrombopathy. Chin. J. Integr. Med. 10, 170–174 (2004). https://doi.org/10.1007/BF02836400
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DOI: https://doi.org/10.1007/BF02836400