Abstract
Nutrient — gene interactions are responsible for maintaining health and preventing or delaying disease. Unbalanced diets for a given genotype lead to chronic diseases such as obesity, diabetes, cardiovascular, and are likely to contribute to increased severity and/or early-onset of many age-related diseases. Many nutrition and many genetic studies still fail to properly include both variables in the design, execution, and analyses of human, laboratory animal, or cell culture experiments. The complexity ofnutrient-gene interactions has led to the realization that strategic international alliances are needed to improve the completeness of nutrigenomic studies — a task beyond the capabilities of a single laboratory team. Eighty-eight researchers from 22 countries recently outlined the issues and challenges for harnessing the nutritional genomics for public and personal health. The next step in the process of forming productive international alliances is the development of a virtual center for organizing collaborations and communications that foster resources sharing, best practices improvements, and creation of databases. We describe here plans and initial efforts of creating the Nutrigenomics Information Portal, a web-based resource for the international nutrigenomics society. This portal aims at becoming the prime source ofinformation and interaction for nutrigenomics scientists through a collaborative effort.
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References
Cardon, L. R. and Bell, J. I. (2001) Association study designs for complex diseases.Nature Reviews Genetics 2, 91–99.
Fuchs, D., Winkelmann, I., Johnson, I. T., Mariman, E., Wenzel, U. and Daniel, H. (2005) Proteomics in nutrition research: Principles, technologies and applications.British Journal of Nutrition 94, 302–314.
Garosi, P., De Filippo, C., van Erk, M., Rocca-Serra, P., Sansone, S. A. and Elliott, R. (2005) Defining best practice for microarray analyses in nutrigenomic studies.British Journal of Nutrition 93, 425–432.
Gibney, M. J., Walsh, M., Brennan, L., Roche, H. M., German, B. and van Ommen, B. (2005) Metabolomics in human nutrition: Opportunities and challenges.American Journal of Clinical Nutrition 82, 497–503.
International HapMap Consortium. (2003) The international hapmap project.Nature 426, 789–796.
International HapMap Consortium. (2004) Integrating ethics and science in the international hapmap project.Nature Reviews Genetics 5, 467–475.
International HapMap Consortium. (2005) A haplotype map of the human genome.Nature 437, 1299–1320.
Ioannidis, J. P. (2005) Why most published research findings are false.Public Library of Science Medicine 2, e124.
Ioannidis, J. R A., Gwinn, M., Little, J., Higgins, J. P. T., Bernstein, J. L., Boffetta, P., Bondy, M., Bray, M. S., Brenchley, P. E., Buffler, P. A., Casas, J. P., Chokkalingam, A., Danesh, J., Smith, G. D., Dolan, S., Duncan, R., Gruis, N. A., Hartge, P., Hashibe, M., Hunter, D. J., Jarvelin, M.-R., Malmer, B., Maraganore, D. M., Newton-Bishop, J. A., O’Brien, T. R., Petersen, G., Riboli, E., Salanti, G., Seminara, D., Smeeth, L., Taioli, E., Timpson, N., Uitterlinden, A. G., Vineis, P., Wareham, N., Winn, D. M., Zimmern, R., Khoury, M. J. and The Human Genome Epidemiology Network and the Network of Investigator, N. (2006) A road map for efficient and reliable human genome epidemiology.Nature Genetics 38, 3–5.
Kaput, J. (2004) Diet-disease gene interactions.Nutrition 20, 26–31.
Kaput, J., Ordovas, J. M., Ferguson, L., van Ommen, B., Rodriguez, R. L., Allen, L., Ames, B. N., Dawson, K., German, B., Krauss, R., Malyj, W., Archer, M. C., Barnes, S., Bartholomew, A., Birk, R., van Bladeren, P., Bradford, K. J., Brown, K. H., Caetano, R., Castle, D., Chadwick, R., Clarke, S., Clement, K., Cooney, C. A., Corella, D., Manica da Cruz, I. B., Daniel, H., Duster, T., Ebbesson, S. O., Elliott, R., Fairweather-Tait, S., Felton, J., Fenech, M., Finley, J. W., Fogg-Johnson, N., Gill-Garrison, R., Gibney, M. J., Gillies, P. J., Gustafsson, J. A., Hartman Iv, J. L., He, L., Hwang, J. K., Jais, J. P., Jang, Y., Joost, H., Junien, C., Kanter, M., Kibbe, W. A., Koletzko, B., Korf, B. R., Kornman, K., Krempin, D. W., Langin, D., Lauren, D. R., Ho Lee, J., Leveille, G. A., Lin, S. J., Mathers, J., Mayne, M., McNabb, W., Milner, J. A., Morgan, P., Muller, M., Nikolsky, Y., van der Ouderaa, F., Park, T., Pensel, N., Perez-Jimenez, F., Poutanen, K., Roberts, M., Saris, W. H., Schuster, G., Shelling, A. N., Simopoulos, A. P., Southon, S., Tai, E. S., Towne, B., Trayhurn, P., Uauy, R., Visek, W. J., Warden, C., Weiss, R., Wiencke, J., Winkler, J., Wolff, G. L., Zhao-Wilson, X. and Zucker, J. D. (2005) The case for strategic international alliances to harness nutritional genomics for public and personal health.British Journal of Nutrition 94, 623–632.
Khoury, M. J. (2004) The case for a global human genome epidemiology initiative.Nature Genetics 36, 1027–1028.
Lander, E. and Kruglyak, L. (1995) Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results [see comments].Nature Genetics 11, 241–247.
Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., Doyle, M., FitzHugh, W., Funke, R., Gage, D., Harris, K., Heaford, A., Howland, J., Kann, L., Lehoczky, J., LeVine, R., McEwan, P., McKernan, K., Meldrim, J., Mesirov, J. P., Miranda, C., Morris, W., Naylor, J., Raymond, C., Rosetti, M., Santos, R., Sheridan, A., Sougnez, C., Stange-Thomann, N., Stojanovic, N., Subramanian, A., Wyman, D., Rogers, J., Sulston, J., Ainscough, R., Beck, S., Bentley, D., Burton, J., Clee, C., Carter, N., Coulson, A., Deadman, R., Deloukas, P., Dunham, A., Dunham, I., Durbin, R., French, L., Grafham, D., Gregory, S., Hubbard, T., Humphray, S., Hunt, A., Jones, M., Lloyd, C., McMurray, A., Matthews, L., Mercer, S., Milne, S., Mullikin, J. C., Mungall, A., Plumb, R., Ross, M., Shownkeen, R., Sims, S., Waterston, R. H., Wilson, R. K., Hillier, L. W., McPherson, J. D., Marra, M. A., Mardis, E. R., Fulton, L. A., Chinwalla, A. T., Pepin, K. H., Gish, W. R., Chissoe, S. L., Wendl, M. C., Delehaunty, K. D., Miner, T. L., Delehaunty, A., Kramer, J. B., Cook, L. L., Fulton, R. S., Johnson, D. L., Minx, P. J., Clifton, S.W., Hawkins, T., Branscomb, E., Predki, P., Richardson, P., Wenning, S., Slezak, T., Doggett, N., Cheng, J. F., Olsen, A., Lucas, S., Elkin, C., Uberbacher, E., Frazier, M., Gibbs, R. A., Muzny, D. M., Scherer, S. E., Bouck, J. B., Sodergren, E. J., Worley, K. C., Rives, C. M., Gorrell, J. H., Metzker, M. L., Naylor, S. L., Kucherlapati, R. S., Nelson, D. L., Weinstock, G. M., Sakaki, Y., Fujiyama, A., Hattori, M., Yada, T., Toyoda, A., Itoh, T., Kawagoe, C., Watanabe, H., Totoki, Y., Taylor, T., Weissenbach, J., Heilig, R., Saurin, W., Artiguenave, F., Brottier, P., Bruls, T., Pelletier, E., Robert, C., Wincker, P., Smith, D. R., Doucette-Stamm, L., Rubenfield, M., Weinstock, K., Lee, H. M., Dubois, J., Rosenthal, A., Platzer, M., Nyakatura, G., Taudien, S., Rump, A., Yang, H., Yu, J., Wang, J., Huang, G., Gu, J., Hood, L., Rowen, L., Madan, A., Qin, S., Davis, R. W., Federspiel, N. A., Abola, A. P., Proctor, M. J., Myers, R. M., Schmutz, J., Dickson, M., Grimwood, J., Cox, D. R., Olson, M. V., Kaul, R., Shimizu, N., Kawasaki, K., Minoshima, S., Evans, G. A., Athanasiou, M., Schultz, R., Roe, B. A., Chen, F., Pan, H., Ramser, J., Lehrach, H., Reinhardt, R., McCombie, W. R., de la Bastide, M., Dedhia, N., Blocker, H., Hornischer, K., Nordsiek, G., Agarwala, R., Aravind, L., Bailey, J. A., Bateman, A., Batzoglou, S., Birney, E., Bork, P., Brown, D. G., Burge, C. B., Cerutti, L., Chen, H. C., Church, D., Clamp, M., Copley, R. R., Doerks, T., Eddy, S. R., Eichler, E. E., Furey, T. S., Galagan, J., Gilbert, J. G., Harmon, C., Hayashizaki, Y., Haussler, D., Hermjakob, H., Hokamp, K., Jang, W., Johnson, L. S., Jones, T. A., Kasif, S., Kaspryzk, A., Kennedy, S., Kent, W. J., Kitts, P., Koonin, E. V., Korf, I., Kulp, D., Lancet, D., Lowe, T. M., McLysaght, A., Mikkelsen, T., Moran, J. V., Mulder, N., Pollara, V.J., Ponting, C. P., Schuler, G., Schultz, J., Slater, G., Smit, A. F., Stupka, E., Szustakowski, J., Thierry-Mieg, D., Thierry-Mieg, J., Wagner, L., Wallis, J., Wheeler, R., Williams, A., Wolf, Y. I., Wolfe, K. H., Yang, S. P., Yeh, R. F., Collins, F., Guyer, M. S., Peterson, J., Felsenfeld, A., Wetterstrand, K. A., Patrinos, A., Morgan, M. J., Szustakowki, J., de Jong, P., Catanese, J. J., Osoegawa, K., Shizuya, H., Choi, S. and Chen, Y. J. (2001) Initial sequencing and analysis of the human genome.Nature 409, 860–921.
Nuffield Council on Bioethics. (2002) The ethics of research related to healthcare in developing countries. 190.
Nuffield Council on Bioethics. (2005) The ethics of research related to healthcare in developing countries: A follow-up discussion paper.
Ordovas, J. M. and Corella, D. (2004) Nutritional genomics.Annual Review of Genomics & Human Genetics 5, 71–118.
Risch, N. (1997) Evolving methods in genetic epidemiology. Ii. Genetic linkage from an epidemiologic perspective.Epidemiology Review 19, 24–32.
Tabor, H. K., Risch, N. J. and Myers, R. M. (2002) Opinion: Candidate-gene approaches for studying complex genetic traits: Practical considerations.Nature Reviews Genetics 3, 391–397.
Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A., Gocayne, J. D., Amanatides, P., Ballew, R.M., Huson, D.H., Wortman, J. R., Zhang, Q., Kodira, C. D., Zheng, X. H., Chen, L., Skupski, M., Subramanian, G., Thomas, P. D., Zhang, J., Gabor Miklos, G. L., Nelson, C., Broder, S., Clark, A. G., Nadeau, J., McKusick, V. A., Zinder, N., Levine, A. J., Roberts, R. J., Simon, M., Slayman, C., Hunkapiller, M., Bolanos, R., Delcher, A., Dew, I., Fasulo, D., Flanigan, M., Florea, L., Halpern, A., Hannenhalli, S., Kravitz, S., Levy, S., Mobarry, C., Reinert, K., Remington, K., Abu-Threideh, J., Beasley, E., Biddick, K., Bonazzi, V., Brandon, R., Cargill, M., Chandramouliswaran, I., Charlab, R., Chaturvedi, K., Deng, Z., Di Francesco, V., Dunn, P., Eilbeck, K., Evangelista, C., Gabrielian, A. E., Gan, W., Ge, W., Gong, F., Gu, Z., Guan, P., Heiman, T. J., Higgins, M. E., Ji, R. R., Ke, Z., Ketchum, K. A., Lai, Z., Lei, Y., Li, Z., Li, J., Liang, Y., Lin, X., Lu, F., Merkulov, G. V., Milshina, N., Moore, H. M., Naik, A. K., Narayan, V. A., Neelam, B., Nusskern, D., Rusch, D. B., Salzberg, S., Shao, W., Shue, B., Sun, J., Wang, Z., Wang, A., Wang, X., Wang, J., Wei, M., Wides, R., Xiao, C., Yan, C., Yao, A., Ye, J., Zhan, M., Zhang, W., Zhang, H., Zhao, Q., Zheng, L., Zhong, F., Zhong, W., Zhu, S., Zhao, S., Gilbert, D., Baumhueter, S., Spier, G., Carter, C., Cravchik, A., Woodage, T., Ali, F., An, H., Awe, A., Baldwin, D., Baden, H., Barnstead, M., Barrow, I., Beeson, K., Busam, D., Carver, A., Center, A., Cheng, M. L., Curry, L., Danaher, S., Davenport, L., Desilets, R., Dietz, S., Dodson, K., Doup, L., Ferriera, S., Garg, N., Gluecksmann, A., Hart, B., Haynes, J., Haynes, C., Heiner, C., Hladun, S., Hostin, D., Houck, J., Howland, T., Ibegwam, C., Johnson, J., Kalush, F., Kline, L., Koduru, S., Love, A., Mann, F., May, D., McCawley, S., McIntosh, T., McMullen, I., Moy, M., Moy, L., Murphy, B., Nelson, K., Pfannkoch, C., Pratts, E., Puri, V., Qureshi, H., Reardon, M., Rodriguez, R., Rogers, Y. H., Romblad, D., Ruhfel, B., Scott, R., Sitter, C., Smallwood, M., Stewart, E., Strong, R., Suh, E., Thomas, R., Tint, N. N., Tse, S., Vech, C., Wang, G., Wetter, J., Williams, S., Williams, M., Windsor, S., Winn-Deen, E., Wolfe, K., Zaveri, J., Zaveri, K., Abril, J. F., Guigo, R., Campbell, M. J., Sjolander, K. V., Karlak, B., Kejariwal, A., Mi, H., Lazareva, B., Hatton, T., Narechania, A., Diemer, K., Muruganujan, A., Guo, N., Sato, S., Bafna, V., Istrail, S., Lippert, R., Schwartz, R., Walenz, B., Yooseph, S., Allen, D., Basu, A., Baxendale, J., Blick, L., Caminha, M., Carnes-Stine, J., Caulk, P., Chiang, Y. H., Coyne, M., Dahlke, C., Mays, A., Dombroski, M., Donnelly, M., Ely, D., Esparham, S., Fosler, C., Gire, H., Glanowski, S., Glasser, K., Glodek, A., Gorokhov, M., Graham, K., Gropman, B., Harris, M., Heil, J., Henderson, S., Hoover, J., Jennings, D., Jordan, C., Jordan, J., Kasha, J., Kagan, L., Kraft, C., Levitsky, A., Lewis, M., Liu, X., Lopez, J., Ma, D., Majoros, W., McDaniel, J., Murphy, S., Newman, M., Nguyen, T., Nguyen, N., Nodell, M., Pan, S., Peck, J., Peterson, M., Rowe, W., Sanders, R., Scott, J., Simpson, M., Smith, T., Sprague, A., Stockwell, T., Turner, R., Venter, E., Wang, M., Wen, M., Wu, D., Wu, M., Xia, A., Zandieh, A. and Zhu, X. (2001) The sequence of the human genome.Science 291, 1304–1351.
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Kaput, J., Astley, S., Renkema, M. et al. Harnessing Nutrigenomics: Development of web-based communication, databases, resources, and tools. Genes Nutr 1, 5–11 (2006). https://doi.org/10.1007/BF02829931
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DOI: https://doi.org/10.1007/BF02829931