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Commercial double-indicator-dilution densitometer using heavy water: Evaluation in oleic-acid pulmonary edema

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Abstract

We evaluated a commercially available, double-indicator-dilution densitometric system for the estimation of pulmonary extravascular water volume in oleic acid-induced pulmonary edema. Indocyanine green and heavy water were used as the nondiffusible and diffusible tracers, respectively. Pulmonary extravascular water volume, measured with this system, was 67% of the gravimetric value (r = 0.91), which was consistent with values obtained from the radioisotope methods. The measured volume was not influenced by changes in cardiac index over a range of 1 to 4 L · min · m2. This system is less invasive than the thermal-dye technique and has potential for repeated clinical measurements of pulmonary extravascular lung water and cardiac output.

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Authors and Affiliations

  1. Department ot Anesthesia, The University of Pennsylvania School ot Medicine, Philadelphia, PA

    Lars G. Leksell, Angelina Sylvestro & Gordon R. Neufeld

  2. The Childrens Hospital ot Philadelphia, Philadelphia, PA

    Mark S. Schreiner

Authors
  1. Lars G. Leksell
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  2. Mark S. Schreiner
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  3. Angelina Sylvestro
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  4. Gordon R. Neufeld
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Leksell, L.G., Schreiner, M.S., Sylvestro, A. et al. Commercial double-indicator-dilution densitometer using heavy water: Evaluation in oleic-acid pulmonary edema. J Clin Monitor Comput 6, 99–106 (1990). https://doi.org/10.1007/BF02828285

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  • DOI: https://doi.org/10.1007/BF02828285

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