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Effect of ginsenoside-Rb1 on cardiomyocyte apoptosis after ischemia and reperfusion in rats

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Summary

The effect of ginsenoside Rb1 on cardiomyocyte apotosis after ischemia (30 min) and reperfusion (6 h) in rats was observed. The ischemia/reperfusion heart model was established by ligating left anterior descending branch of coronary artery in Wistar rats. The apoptotic cardiomyocytes were examined under transmission electron microscopy and counted byin situ nick end labeling (TUNEL) method and light microscopy. Results showed that (1) The apoptotic cardiomyocytes were found in ischemic regions in the ischemia/reperfusion group, but not in the sham-operating group under transmission electron microscopy; (2) The number of apoptotic cells were 134.45±45.61/field in the ischemia/reperfusion group, 0/field in the sham-operating group and 51.65±13.71/field in the ginsenoside Rb1-treated group. The differences were significant among the three groups (P<0.01). It was concluded that myocardial ischemia-reperfusion could induce cardiomyocyte apoptosis, and ginsenoside Rb1 could significantly inhibit cardiomyocyte apoptosis induced by ischemia-reperfusion in rats, indicating that ginsenoside Rb1 could inhibit cardiomyocyte apoptosis induced by ischemia-reperfusion, thus alleviating ischemia-reperfusion injury.

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Author notes

  1. Guan Li

    Present address: Department of Cardiology, People's Hospital of Luohu District, 518001, Shenzhen

Authors and Affiliations

  1. Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan

    Guan Li & Liu Zhengxiang

  2. Xiaogan Central Hospital, Operating Room, 432100, Xiaogan

    Li Weizhen

Authors
  1. Guan Li
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  2. Li Weizhen
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  3. Liu Zhengxiang
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Additional information

GUAN Li, female, born in 1967, Doctor in Charge

This project was supported by a grant from the Natural Science Foundation of Hubei Province (Serial No. 2000J050).

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Li, G., Weizhen, L. & Zhengxiang, L. Effect of ginsenoside-Rb1 on cardiomyocyte apoptosis after ischemia and reperfusion in rats. Current Medical Science 22, 212–215 (2002). https://doi.org/10.1007/BF02828182

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  • DOI: https://doi.org/10.1007/BF02828182

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