Summary
To further investigate the vertical transmission route of human papillomavirus (HPV) and the indication for the choice of mode of delivery, the infective status of 152 asymptomatic pregnant wemen and the maternal-fetal transmission were studied. By using general primers in polymerase chain reaction (GP-PCR) combined with restriction fragment length polymorphism analysis, HPV DNA positive rate in cervical secretions and venous blood in asymptomatic pregnant women was 36.21% and 52.78%, respectively, and the identified genotypes were mainly HPV16 and18. The maternal-fetal transmission rate of HPV via genital tract as well as blood was 40.91% and 57. 89%, respectively. It was concluded that besides the transmission route of genital tract and amniotic fluid, there was also transplacental transmission of HPV in utero. Therefore, in our opinion, it is not an absolut indication to perform a cesarean delivery for the pregnant women with HPV asymtomatic genital infection.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Chan P K, Li W II, Chan M Yet al. High prevalence of human papillomavirus type 58 in Chinese women with cervical cancer and precancerous lesions. J Med Virol, 1999, 59: 232
Rice P S, Mant C, Cason Jet al. High prevalence of human papillomavirus type 16 infection among children. J Med Virol, 2000, 61: 70
Tenti P, Zappatore R, Migliora Pet al. Perinatal transmission of human papillomavirus from gravidas with latent infections. Obstet Gynecol, 1999, 93: 475
Eppel W, Worda G, Frigo Pet al. Human papillomavirus in the cervix and placenta. Obstet Gynecol, 2000, 96: 337
Hagensee M E, Slavinsky J, Gaffga C Met al. Seroprevalence of human papillomavirus type 16 in pregnant women. Obstet Gynecol, 1999, 94: 653
Marrison E A B, Gammon M D, Goldberg G Let al. Pregnancy and cervical infection with human papillomavirus. Int J Gynecol Obstet, 1996, 54: 124
Cason J. Pernatal acquisition of cervical cancer-associated papillomaviruses. Br J Obstet Gynaecol, 1996, 103: 853
Silverberg M J, Thorsen M P, Lindeberg Het al. Condyloma in pregnancy is strongly predictive of juvenile-onset recurrent respiratory papillomatosis. Obstet Gynecol, 2003, 101: 645
Tseng C J, Lin C Y, Soong Y Ket al. Perinatal transmission of human papillomavirus in infants. Relationship between infection rate and mode of delivery. Obstet Gynecol, 1998, 91: 92
Author information
Authors and Affiliations
Additional information
DENG Dongrui, female, born in 1966, Associate Professor
Rights and permissions
About this article
Cite this article
Dongrui, D., Liangzhen, W., Wen, C. et al. Asymptomatic genital infection of human papillomavirus in pregnant women and the vertical transmission route. Current Medical Science 25, 343–345 (2005). https://doi.org/10.1007/BF02828162
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02828162