Summary
As the myocardium in patients with dilated cardiomyopathy (DCM) is deteriorating progressively, resulting in a decrease in left ventricular function, patients with end-stage DCM may require implantation of a left ventricular assist device (LVAD) unless they undergo heart transplantation. Although LVAD has been reported to provide excellent hemodynamic support, no data are currently available about the effects of long-term LVAD support on the myocardium in patients with DCM. We describe two patients with end-stage DCM who underwent LVAD implantation and were supported with LVAD for 524 and 245 days, respectively. Serial myocardial biopsies showed increases in myocardial cell diameter and intercellular fibrosis, despite excellent hemodynamic support by LVAD. These data suggest that the myocardium in patients with end-stage DCM deteriorates progressively, even if the preload of the left ventricle is reduced by LVAD.
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Frasier OH, Benedict CR, Radovancevic B, Radovancevic B, Biek RJ, Capek P, Springer WE, Macris MP, Delgado R, Buja LM. (1996) Improved left ventricular function after chronic left ventricular unloading. Ann Thorac Surg 62:675–682
Kormos RL, Murali S, Dew MA, Armitage JM, Hardesty RL, Borovetz HS, Griffith BP (1994) Chronic mechanical circulatory support: rehabilitation, low morbidity, and superior survival. Ann Thorac Surg 57:51–58
WHO (1980) Report of the WHO/ISFC task on the definition and classification of cardiomyopathies. Br Heart J 44:672–673
Scheinin SA, Capek P, Radovancevic B, Duncan JM, McAllister HA Jr, Frazier OH (1992) The effect of prolonged left ventricular support on myocardial histopathology in patients with end-stage cardiomyopathy. ASIO J 38:M271-M274
McCarthy PM, Nakatani S, Vargo R, Marchant KK, Harasaki H, James KB, Savage RM, Thomas JD. (1995) Structural and left ventricular histologic changes after implantable LVAD insertion. Ann Thorac Surg 59:609–613
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Taketani, S., Sawa, Y., Fukushima, N. et al. Myocardial histological changes in dilated cardiomyopathy during a long-term left ventricular assist device support. Heart Vessels 12, 98–100 (1997). https://doi.org/10.1007/BF02820873
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DOI: https://doi.org/10.1007/BF02820873