Abstract
We studied the appearance of the thymus primordia of main representatives of the vertebrate evolution, observed these anlages in different places of the branchial region and followed their gradual reduction in phyletic line. On the assumption that the thymus potency has been encoded in evolution, we studied the human thymus ontogeny and described the entodermal thymus primordia not only in the 3rd but also in the 2nd and 4th pouch. We describe a very important contribution of the ectodermal canaliculus, projecting from the 3rd cleft, as well as the participation of the hypobranchial neural placode to the definitive thymus formation. Even though the entodermal thymus primordium in the 2nd pouch has reached an advanced stage, the thymus cannot complete its development because the ento-ectodermal relation is missing. In addition to this dysgenesis, we describe thymic involution in a later fetal period in connection with some malformations and confirm the close relation between the central immune organ and the neuro-endocrine system.
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References
Beranová M., Slípka J.: Immune-neuro-endocrine relations in teratology. (In Czech)Plzeň. Lék. Sbornik 63, 243–245 (1996).
Bockman D.E., Kirby M.L.: Dependence of thymus development on derivatives of neural crest.Science 223, 498–500 (1984).
Borisov I.N., Dunaev P.B., Bažanov A.N.:Phylogenetic Principles of the Tissue Organization in Animals. (In Russian) Nauka, Novosibirsk 1986.
von Gaudecker B.: Functional histology of the human thymus.Anat. Embryol. 183, 1–15 (1991).
Holub M.:Immunology of the Nude Mice. CRC Press, Boca Raton 1989.
Le Douarin N.M., Jotereau F.V., Houssaint E., Thiery J.-P.: Primary lymphoid organ ontogeny in birds, pp. 179–216 in N.M. Le Douarin, A. Mc Laren (Eds):Chimeras in Developmental Biology. Academic Press, London 1984.
Nezelof C.: Pathology of the thymus in immunodeficiency states, pp. 151–177 in H.K. Müller-Hermelink (Ed.):The Human Thymus. Springer-Verlag, Berlin 1986.
Northcutt R.G., Gans C.: The genesis of neural crest and epidermal placodes. A reinterpretation of vertebrate orgins.Quart. Rev. Biol. 58, 1–2 (1983).
Pospíšilová V., Slípka J.: Does the thymus develop in the third branchial pouch only?Funct. Develop. Morphol. 4, 247–248 (1994).
Pospíšilová V., Slípka J.: Ekto-entodermale Beziehungen in der Entwicklung des Thymus.Verh. Anat. Ges. Suppl. 179, 299 (1997).
Schwartz A., Slípka J.: Accidental thymus involution, pp. 78–82 inProc. Conf. Development of the Immune Response (A. Macela, P. Popper, Eds) (In Czech). J.E. Purkyně Military Medical Academy, Hradec Králové (1990).
Slípka J.: Evolutionary morphology of the branchial region as the reflection of environmental changes, pp. 203–211 in V. Nováket al. (Eds):Behaviour, Adaptation and Evolution. Academia, Prague 1986.
Slípka J., Pospíšilová V.: “Thymus secundus” beim Menschen.Ann. Anat. 177, 386 (1995).
Šima P., Větvička V.:Evolution of Immune Reactions. CRC Press, Boca Raton 1990.
Webb J.F., Noden D.M.: Ectodermal placodes: Contribution to the development of the vertebrate head.Amer. Zool. 33, 434–497 (1993).
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Slípka, J., Pospíšilová, V. & Slípka, J. Evolution, development and involution of the thymus. Folia Microbiol 43, 527–530 (1998). https://doi.org/10.1007/BF02820813
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DOI: https://doi.org/10.1007/BF02820813