Abstract
The potential ofC. tropicalis to colonize and infect rat tongue mucosa was demonstrated. Thirty female Sprague-Dawley rats were infected orally with three different strains ofC. tropicalis. The animals were killed one and three weeks following the inoculation and sections of their tongue were stained with hematoxylin-eosin and Grocott stain. Histological changes were observed in the group of animals killed one week after inoculation and infected withC. tropicalis strain isolated from the crural ulcer of a diabetic patient. The most important finding was acute purulent myositis with the formation of abscesses. The myositis was local without signs of spreading to the surrounding tissue. Epithelium-penetrating hyphae observed in the Grocott-stained sections were relatively fewer and more sparsely distributed.
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References
Allen C.M., Beck F.M.: Strain-related differences in pathogenicity ofCandida albicans for oral mucosa.J. Infect. Dis.147, 1036–1040 (1983).
Allen C.M., Beck F.M.: Differences in mucosal reaction related toCandida albicans isolates.J. Oral Pathol.16, 89–93 (1987).
Allen C.M., Paulson R., Duncan R.: Clinical, histologic and scanning electron microscopic study of the development of chronic candidiasis of the rat tongue.J. Oral. Pathol. Med.18, 352–359 (1989).
Barret A.W., Kingsmill V.J., Speight P.M.: The frequency of fungal infection in biopsies of oral mucosal lesions.Oral Dis.4, 26–31 (1998).
Cawson R.A., Lehner T.: Chronic hyperplastic candidiasis—candidal leukoplakia.Brit. J. Dermatol.80, 9–16 (1966).
Dorko E., Ďurovičová J.: Possibilities of laboratory diagnosis of oral candidosis. (In Slovak)Stomatológ7, 5–7 (1997).
Dorko E., Ďurovičová J.: Presentation of yeasts species in clinical material of patients with oral candidosis. (In Slovak)Stomatológ7, 7–8 (1998).
Dorko E., Ďurovičová J., Dorko F.: Oral candidiasis and stomatitis prosthetica.Progresdent4, 8–9 (1999).
Dorko E., Kmeťová M., Pilipčinec E., Bračoková I., Dorko F., Danko J., Švický E., Tkáčiková L'.: Rare non-albicans Candida species detected in different clinical diagnoses.Folia Microbiol.45, 364–368 (2000a).
Dorko E., Kmeťová M., Dorko F., Škardová I.: Incidence ofCandida tropicalis in clinical samples over 5-year period.Pak. J. Biol. Sci.3, 606–609 (2000b).
Dorko E., Bračoková I., Sokoi L., Bodnár J., Dorko F., Švorc P., Marossy A., Štimmelová J.: Experimental candidosis of the rat tongue (In Slovak)Slov. Vet. Čas.25, 99–102 (2000c).
Field E.A., Field J.K., Martin M.V.: DoesCandida have a role in oral epithelial neoplasia?J. Med. Vet. Mycol.27, 277–294 (1989).
Jautová J., Jarčušková D., Dubivská M.: A share of immunologic changes in ethiopathogenesis ofcandidosis.Folia Fac. Med. Univ. Šafarikianae Cassoviensis52, 137–139 (1995a).
Jautová J., Jarčušková D., Dubivská M., Šimuničová E.: Torpid course of candidosis in a patient with collins syndrome. (In Slovak)Čs. Dermatol.70, 203–205 (1995b).
Jautová J., Jarčušková D., Dubivská M., Petrovičová J.: Therapeutic approach to onychomycoses of fungal origin in a female patient with atopic dermatitis. (In Slovak)Čs. Pediatr.51, 109–113 (1996).
Jones J.H., Russell C.: The histology of chronic candidal infection of the rat's tongue.J. Pathol.113, 97–100 (1974).
King R.D., Lee J.C., Morris A.L.: Adherence ofCandida albicans and otherCandida species to mucosal epithelial cells.Infect. Immun.27, 667–674 (1980).
Martinez-Machin G., Perurena-Lancha G.M., Nunez-Carvajalan C.M., Fernandez-Andreu C.M., Bandera-Tirado F.: Isolation, identification, and typing of yeasts from HIV-positive patients with oral candidiasis.Rev. Cubana Med. Trop.49, 174–180 (1997).
Mechírová E., Zachariáš L., Belej K., Szabóová O.:Histology (In Slovak) Tranox, Košice 1995.
Nucci M., Silveira M.J., Spector N., Silveira F., Velasco E., Martins C.A., Derrosi A., Colombo A.L., Pulcheri W.: Fungemia in cancer patients in Brasil: predominance of non-albicans species.Mycopathologia141, 65–68 (1998).
Odds F.C., Bernaerts R.: CHRO MagarCandida, a new differential isolation medium for presumptive identification of clinically importantCandida species.J. Clin. Microbiol.32, 1923–1929 (1994).
O'Grady J.F., Reade P.C.:Candida albicans as a promoter of oral mucosal neoplasia.Carcinogenesis13, 783–786 (1992).
Otčenášek M.:Identification Methods of the Mycotic Diseases. (In Czech) Avicenum, Prague 1990.
Pindborg J.J.: Oral leukoplakia.Austral. Dent. J.16, 83–89 (1971).
Reed M.F., Scragg M.A., Williams D.M., Soames J.V.:In vivo effects ofCandida albicans products on rat oral epithelium.J. Oral Pathol. Med.19, 326–329 (1990).
Rodero L., Boutureira M., Demkura H., Burkett A., Fernandez C., Losso M., Jauregui-Rueda H., Monticelli A., Vitale R., Canteros C., Hochenfellner F., Vivot W., Davel G.: Yeast infections: causative agents and their antifungal resistance in hospitalized pediatric patients and HIV-positive adults.Rev. Argent. Microbiol.29, 7–15 (1997).
Russell C., Jones J.H.: The histology of prolonged candidal infection of the rat's tongue.J. Oral. Pathol.4, 330–339 (1975).
Samaranayake Y.H., Wu P.C., Samaranayake L.P., Ho P.L.: The relative pathogenicity ofCandida krusei andCandida albicans in the rat oral mucosa.J. Med. Microbiol.47, 1047–1057 (1998).
Silverman S., Gorsky M., Lozada P.: Oral leukoplakia and malignant transformation.Cancer53, 563–568 (1984).
Slutsky B., Buffo J., Soll D.R.: High-frequency switching of colony morphology inCandida albicans.Science230, 666 (1985).
Tomšíková A.: New yeast pathogens—agents of nosocomial mycoses.Folia Microbiol.44, 118 (1999).
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Dorko, E., Pilipčinec, E., Bračoková, I. et al. Relative pathogenicity ofCandida tropicalis in rat tongue mucosa. Folia Microbiol 45, 561–565 (2000). https://doi.org/10.1007/BF02818727
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DOI: https://doi.org/10.1007/BF02818727