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Gentamicin resistance in clinical strains ofEnterobacteriaceae associated with reduced gentamicin uptake

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Abstract

Seven strains ofEnterobacteriaceae resistant to gentamicin obtained as representatives of the predominant resistance profiles in the clinical laboratories ofRafeidia and Al-Watani Hospitals in Nablus (Palestine) were included. Five strains showed a broad aminoglycoside resistance profile but contained no evidence of gentamicin acetylation, adenylation, or phosphorylation. Gentamicin uptake in two tested strains was significantly reduced, compared to that of gentamicin-sensitiveE. coli (MIC, 0.5 μg/mL.) These strains are likely resistant due to a relative reduction of the amount of gentamicin and other aminoglycosides entering the bacterial cell. Two strains showed evidence of adenyltransferase ANT (2")-I activity.

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Authors and Affiliations

  1. Department of Biological Sciences, An-Najah N. University, Nablus, Palestine

    K. Adwan & N. Abu-Hasan

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  1. K. Adwan
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  2. N. Abu-Hasan
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Adwan, K., Abu-Hasan, N. Gentamicin resistance in clinical strains ofEnterobacteriaceae associated with reduced gentamicin uptake. Folia Microbiol 43, 438–440 (1998). https://doi.org/10.1007/BF02818588

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  • DOI: https://doi.org/10.1007/BF02818588

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