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Some aspects of overproduction of secondary metabolites

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Abstract

Different approaches used to increase production of secondary metabolites and construct overproducing strains of microorganisms are reviewed. Overproduction of secondary metabolites incuudes the physiological control,e.g. feed-back inhibition, carbon and energy source regulation, nitrogen source regulation, phosphate regulation and the effect of autoregulatory compounds. The genetic control of overproduction of secondary metabolites includes mechanisms similar to those controlling the expression of primary metabolism coding genes, although the genes specifying biosynthesis of secondary metabolites and their expression have some particular features. Possible future trends in the study of overproduction of secondary metabolites are discussed.

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  1. Institute of Microbiology, Academy of Sciences of the Czech Republic, 142 20, Prague 4

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Dedicated to the 70th birthday of Dr. Z. Vanêk

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Spížek, J., Tichý, P. Some aspects of overproduction of secondary metabolites. Folia Microbiol 40, 43–50 (1995). https://doi.org/10.1007/BF02816527

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