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Enzymic and permeability activity ofPseudomonas aeruginosa after treatment with sub-MICs of organic ammonium salts

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Abstract

The effects of subinhibitory concentrations (1/4, 1/8, 1/16 of the MIC) of 12 organic ammonium salts of A (hard— alkyltrimethylammonium bromides) and B (soft—2-(dodecanoylamino)ethylalkyldimethylammonium bromides) homologous series on phospholipase C, proteinase, elastase and permeability activity were studied. The substances with longer substituents were more effective in reducing phospholipase C activity (hard and soft series) as well as proteinase (hard series). Phospholipase C was the most frequently and the most markedly inhibited enzyme. The organic ammonium salts were less effective in inhibiting elastase and permeability activity. Only one of the substances under study reduced all the tested activities.

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  1. Institute of Preventive and Clinical Medicine, 833 01, Bratislava, Slovakia

    A. Hoštacká & V. Majtán

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  1. A. Hoštacká
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  2. V. Majtán
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Hoštacká, A., Majtán, V. Enzymic and permeability activity ofPseudomonas aeruginosa after treatment with sub-MICs of organic ammonium salts. Folia Microbiol 39, 197–202 (1994). https://doi.org/10.1007/BF02814648

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