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Lipid peroxidation products, and vitamin and trace element status in patients with cancer before and after chemotherapy, including adriamycin

A preliminary study

  • Part III Cancer and Immunity
  • Published:
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Abstract

Adriamycin is a potent chemotherapeutic agent used in the treatment of human neoplastic diseases. A major side effect limiting the use of this drug is its toxic effect on the heart. Several hypotheses have been proposed to explain the cardiotoxicity of Adriamycin. However, the most plausible hypothesis seems to be the reduction of Adriamycin and free radical production, which induces lipid peroxidation and oxidative damages in the heart.

We have thus undertaken this preliminary study to investigate Adriamycin-induced lipid peroxidation by the measurement of plasma thiobarbituric acid reactant materials and antioxidant systems, namely glutathione content, glutathione peroxidase activity, and vitamin and trace element status, in patients with cancer before and after chemotherapy, including Adriamycin.

The concentration of thiobarbituric acid reactant materials in plasma of patients with cancer was higher than in controls and was further increased after chemotherapy. Blood glutathione and plasma glutathione peroxidase activity, as well as plasma zinc and selenium in patients with cancer, were decreased, but not further modified by chemotherapy. However, only zinc and selenium levels reached a significant level. In contrast, plasma vitamin E and β-carotene levels were not significantly increased in patients with cancer. Finally, plasma vitamin A and copper levels were not modified either in patients with cancer or by chemotherapy.

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Abbreviations

ADR:

Adriamycin

GSH:

reduced glutathione

GSSG:

oxidized glutathione

GPx:

glutathione peroxidase

OHP:

organic hydroperoxides

TBARMs:

thiobarbituric acid reactant materials

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Authors and Affiliations

  1. Laboratoire de Biochimie C, Hôpital Albert Michallon, BP 217 X, F-38043, Grenoble Cedex, France

    Michel Faber, Charles Coudray, Hassan Hida & Alain Favier

  2. Service d’Oncologie, Hôpital Albert Michallon, Grenoble Cedex, France

    Mireille Mousseau

  3. Faculté de Médecine et de Pharmacie, Groupe de Recherche sur les Pathologies Oxydatives (Grepo), La Tronche, France

    Alain Favier

Authors
  1. Michel Faber
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  2. Charles Coudray
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  3. Hassan Hida
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  4. Mireille Mousseau
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  5. Alain Favier
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Faber, M., Coudray, C., Hida, H. et al. Lipid peroxidation products, and vitamin and trace element status in patients with cancer before and after chemotherapy, including adriamycin. Biol Trace Elem Res 47, 117–123 (1995). https://doi.org/10.1007/BF02790108

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  • DOI: https://doi.org/10.1007/BF02790108

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