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Effect of antioxidants on adriamycin-induced microsomal lipid peroxidation

  • Part III Cancer and Immunity
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Abstract

Adriamycin (25 μM) stimulated NADPH-dependent microsomal lipid peroxidation about fourfold over control values. The tested antioxidants, zinc, superoxide dismutase, vitamin E, and desferrioxamine (Desferal) inhibited Adriamycin-enhanced lipid peroxidation to varying degrees. Others antioxidants, e.g., glutathione, catalase, and selenium, were found to have no effects. Our in vitro studies suggest that adriamycin effect is mediated by a complex oxyradical cascade involving superoxide, hydroxyl radical, and small amounts of iron.

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Abbreviations

ADR:

adriamycin

GSH:

glutathione

OHP:

organic hydroperoxides

MDA:

malondialdehyde

ROS:

reactive oxygen species

SOD:

superoxide dismutase

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Authors and Affiliations

  1. Groupe de Recherche sur les Pathologies Oxydatives (GREPO), Laboratoire de Pharmacie Clinique et Biotechniques, UJF, Faculté de Pharmacie, La Tronche, France

    Hassan Hida & Jean Calop

  2. Groupe de Recherche sur les Pathologies Oxydatives (GREPO), Laboratoire de Biochimie des Micronutriments et Radicaux Libres, CHRU de Grenoble, BP 217X, 38043, Grenoble Cedex, France

    Charles Coudray & Alain Favier

Authors
  1. Hassan Hida
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  2. Charles Coudray
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  3. Jean Calop
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  4. Alain Favier
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Hida, H., Coudray, C., Calop, J. et al. Effect of antioxidants on adriamycin-induced microsomal lipid peroxidation. Biol Trace Elem Res 47, 111–116 (1995). https://doi.org/10.1007/BF02790107

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  • DOI: https://doi.org/10.1007/BF02790107

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