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Role of cytokines in pulmonary antimicrobial host defense

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Abstract

Host defense of the lung is characterized by a fine balance between the generation of a vigorous inflammatory response to clear pathogens and maintenance of the integrity of the alveolar gas-exchange surface. The magnitude of the inflammatory response is therefore tightly regulated by pro- and anti-inflammatory cytokine mediators. This article summarizes current information on the roles of specific cytokines in pneumonia, with particular emphasis on ongoing investigations into the role of innate immunity in bacterial and fungal pneumonia.

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Abbreviations

CLP:

cecal ligation and puncture

G-CSF:

granulocyte colonystimulating factor

GM-CSF:

granulocyte/macrophage colonystimulating factor

IFN-γ:

interferon-γ

IL-lΒ:

interleukin-lΒ

IL-6:

interleukin-6

IL-8:

interleukin-8

IL-10:

interleukin-10

IL-12:

interleukin-12

LPS:

lipopolysaccharide

MCP-1:

monocyte chemoattractant protein-1

MlP-lα:

macrophage inflammatory protein-1 α

MIP-1Β:

macrophage inflammatory protein-1Β

MIP-2:

macrophage inflammatory protein-2

PDGF:

platelet-derived growth factor

r:

recombinant

RANTES:

regulated upon activation in normal T cells expressed and secreted

TGF-Β:

transforming growth factor-Β

TNF:

tumor necrosis factor-α

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Authors and Affiliations

  1. Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI

    Borna Mehrad & Theodore J. Standiford

  2. University of Michigan Medical Center, 6301 MSRB III 1150 West Medical Center Drive, 48109-0360, Ann Arbor, MI

    Borna Mehrad

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  1. Borna Mehrad
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  2. Theodore J. Standiford
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Correspondence to Borna Mehrad.

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Mehrad, B., Standiford, T.J. Role of cytokines in pulmonary antimicrobial host defense. Immunol Res 20, 15–27 (1999). https://doi.org/10.1007/BF02786504

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