Abstract
The role of self-antigen recognition in the development of T and B cells of the adaptive immune system has been studied in several different ways. We have shown that CD4 T cells are selected on selfpeptide:self-MHC class II ligands, and in the periphery, they are sustained by contact with the same or similar ligands. We have also observed that B cells are positively selected on unknown and presumed self-ligands. We have used this information to explore autoimmune diseases as well. Finally, we have recently identified the innate immune system as playing a crucial role in regulating expression of costimulatory molecules that are required for induction of adaptive immune responses.
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People whose work is included in this review are as follows: Chuck Annicelli, Joanne Appicelli, Avlin Barlow, Jody Baron, Michael Carrithers, Chaoqun Chen, Alexander Chervonsky, Beth Cohen, Bonnie Dittel, Tori Evans, Jennifer Granata, Fridrika Hardardottir, Xin He, Jon Kaye, Matthew Levine. Yang Liu, Grigori Loysev, Ruslan Medzhitov, Paula Preston-Hurlburt, Eve Robinson, Alexander Rudensky, Derek Sant’Angelo, John Shanabrough, Christophe Viret, Irene Visintin, and Sue Wong
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Janeway, C.A. The role of self-recognition in receptor repertoire development. Immunol Res 19, 107–118 (1999). https://doi.org/10.1007/BF02786480
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DOI: https://doi.org/10.1007/BF02786480